Welcome to Institut für Physikalische Biologie

The function of each cell and each organism decisively depends on the dynamic interactions between biological macromolecules and on their correct three-dimensional structure. Faulty interaction and incorrectly folded structures eventually lead to diseases and ageing. Our aim is to understand these interactions and to determine the three-dimensional structure of the protein complexes involved in decisive cellular processes - if possible, in atomic resolution. Beyond that, we develop novel methods for the early diagnosis and treatment of neurodegenerative diseases, with a strong focus on Alzheimer's dementia. undefined[more]

Prof. Dr. Dieter Willbold is the director of the institute. His Department focusses on Modelling Systems, Virus-Host-Interaction and Neurofunction/Neurodegeneration. undefined[more] The Department of Prof. Dr. Henrike Heise is developing new methods in the field of solid state NMR-Spektroscopy.
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A close cooperation exists with the undefinedInstitute of Complex Systems (ICS-6: Structural Biochemistry) at Forschungszentrum Jülich, which is also headed by Prof. Dr. Willbold. Together, the two institutes run the undefinedBiomolecular NMR-Center in Jülich.

A close cooperation exists with the undefinedInstitute of Complex Systems (ICS-6: Structural Biochemistry) at Forschungszentrum Jülich, which is also headed by Prof. Dr. Willbold.

Together, the two institutes run the Biomolecular NMR-Center in Jülich.

21.09.17 World Alzheimer’s Day: Interview with Prof. Dieter Willbold

On September 21, the international World Alzheimer’s Day, Prof. Willbold has given an interview to the Biophysical Society on how biophysics research contributes to understanding Alzheimer’s Disease.


08.09.17 Science: Sharpest Image of Alzheimer’s Fibrils Shows Previously Unknown Details

A team of researchers from Germany and the Netherlands have determined the structure of an amyloid fibril with previously unachieved resolution. The fibrils of the body’s own amyloid beta (Aβ) protein are the main constituent of Alzheimer’s disease related and characteristic pathological protein deposits in the brain. The atomic-level three-dimensional structure elucidated by scientists from Forschungszentrum Jülich, Heinrich Heine University Düsseldorf, the Centre for Structural Systems Biology in Hamburg, and Maastricht University displays previously unknown structural details which can answer many questions on the growth of harmful deposits and also explain the effect of genetic risk factors. The results have been published in the renowned journal Science.


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