Publikationen in 2012

  • Aigner K, Dreßen F, Steger G 
    Methods for Predicting RNA Secondary Structure 
    In "Nucleic Acids and Molecular Biology: RNA 3D Structure Analysis and Prediction" (Leontis N, Westhof E) 27, 19-42 (2012)  
  • Bannach O, Birkmann E, Reinartz E, Jaeger K-E, Langeveld JP, Rohwer RG, Gregory L, Terry LA, Willbold D, Riesner D 
    Detection of Prion Protein Particles in Blood Plasma of Scrapie Infected Sheep 
    PLoS ONE 7, e36620 (2012)  
    full text open access  
  • Brunger AT, D Das, AM Deacon, J Grant, TC Terwilliger, RJ Read, PD Adams, M Levitt and GF Schröder 
    Application of DEN-Refinement And Automated Model-Building To A Difficult Case Of Molecular Replacement Phasing: The Structure Of A Putative Succinyl-Diaminopimelate Desuccinylase From Corynebacterium Glutamicum. 
    Acta Cryst. D 68, 391 (2012) 
  • Brunger AT, PD Adams, P Fromme, R Fromme, M Levitt, and GF Schröder 
    Improving the accuracy of macromolecular structure refinement at 7 Å resolution. 
    Structure 20(6), 957 (2012) 
  • Circolone F, Granzin J, Jentzsch K, Drepper T, Jaeger K-E, Willbold D, Krauss U, Batra-Safferling R 
    Structural basis for the slow dark recovery of a full-length LOV protein from Pseudomonas putida. 
    J. Mol. Biol. 417, 362–374 (2012) 
  • Ellinger P, Arslan Z, Wurm R, Ries B, MacKenzie C, Pfeffer K, Panjikar S, Wagner R, Schmitt L, Gohlke H, Pul U, Smits SHJ 
    The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae 
    J. Struct. Biol. 178 (3), 350-62 (2012) 
    full text  
  • Feuerstein S, Plevin MJ, Willbold D, Brutscher B 
    iHADAMAC: a complementary tool for sequential resonance assignment of globular and highly disordered protein. 
    J. Magn. Res. 214, 329-334 (2012) 
  • Feuerstein S, Solyom Z, Aladag A, Favier A, Schwarten M, Hoffmann S, Willbold D, Brutscher B 
    Transient structure and SH3 interaction sites in an intrinsically disordered fragment of the hepatitis C virus protein NS5A. 
    J. Mol. Biol. 420, 310-323 (2012) 
  • Funke SA, Bartnik D, Glück JM, Pirkowska K, Wiesehan K, Weber U, Gulyas B, Halldin C, Pfeifer A, Spenger C, Muhs A, Willbold D 
    Development of a small D-enantiomeric Alzheimer's amyloid-beta binding peptide ligand for future in vivo imaging applications. 
    PLoS ONE 7, e41457 (2012) 
  • Funke SA, Liu H, Sehl T, Bartnik D, Brener O, Nagel-Steger L, Wiesehan K, Willbold D 
    Identification and characterization of an Aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer’s disease. 
    Rejuv. Res. 15, 144-147 (2012) 
  • Funke SA, Willbold D 
    Peptides for Therapy and Diagnosis of Alzheimer’s Disease. 
    Curr. Pharm. Design 18, 755-767 (2012) 
  • Granzin J, Cousin A, Weirauch M, Schlesinger R, Büldt G, Batra-Safferling R 
    Crystal structure of p44, a constitutively active splice variant of visual arrestin. 
    J Mol Biol. 416(5), 611-8 (2012)  
  • Gulyás B, Spenger C, Beliczai Z, Gulya K, Kása P, Jahan M, Jia Z, Weber U, Pfeifer A, Muhs A, Willbold D, Halldin C 
    Distribution and binding of (18)F-labeled and (125)I-labeled analogues of ACI-80, a prospective molecular imaging biomarker of disease: A whole hemisphere post mortem autoradiography study in human brains obtained from Alzheimer's disease patients. 
    Neurochem. Intern. 60, 153-162 (2012) 
  • Hammann C, Steger G 
    Viroid-specific small RNA in plant disease 
    RNA Biology 9, 809-819 (2012)  
  • Henderson R, A Sali, ML Baker, B Carragher, B Devkota, KH Downing, EH Egelman, Z Feng, J Frank, N Grigorieff, W Jiang, SJ Ludtke, O Medalia, PA Penczek, PB Rosenthal, MG Rossmann, MF Schmid, GF Schröder, AC Steven, DL Stokes, JD Westbrook, W Wriggers, H Yang, J Young, HM Berman, W Chiu, GJ Kleywegt, CL Lawson 
    Outcome of the First Electron Microscopy Validation Task Force Meeting. 
    Structure 20, 205 (2012) 
  • Holze R, Jacob T, Schünke S, Neudecker P, Willbold D 
    Physical Chemistry 2011 
    Nachr. Chemie 60, 313-322 (2012) 
  • Hübinger S, Bannach O, Funke SA, Willbold D, Birkmann E 
    Detection of alpha-synuclein aggregates by fluorescence microscopy 
    Rejuvenation Res. 15, 213-216 (2012) 
  • Jahan M, Nag S, Krasikova R, Weber U, Muhs A, Pfeifer A, Spenger C, Willbold D, Gulyás B, Halldin C 
    Fluorine-18 labeling of three novel d-peptides by conjugation with N-succinimidyl-4-[(18)F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography. 
    Nucl. Med. Biol. 392, 315-323 (2012) 
  • Kammula E, Moetter J, Gorgels A, Jonas E, Hoffmann S, Willbold D 
    Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. 
    PLoS ONE 7, e51578 (2012)  
    full text open access  
  • Klionsky DJ, et al, Willbold D, et al (many co-authors) 
    Guidelines for the use and interpretation of assays for monitoring autophagy. 
    Autophagy 8, 445-544 (2012) 
  • Koenig BW, Schünke S, Stoldt M, Willbold D 
    NMR methods for the determination of protein-ligand interactions. 
    Protein-Ligand Interactions" (Editor: H. Gohlke) (series "Methods and Principles in Medicinal Chemistry"), Wiley-VCH; ISBN: 3-527-32966-8, (2012) 
  • Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, Pilar López-Deber M, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A 
    Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. 
    J. Biol. Chem. 287, 34786-34800 (2012) 
  • Lecher J, Schwarz CKW, Stoldt M, Smits SHJ, Willbold D, Schmitt L 
    RTX toxin transporters tether its substrate prior to secretion via the unique function of its N- terminal domain. 
    Structure 20, 1778-1787 (2012) 
  • Luers L, Rysiewksi K, Dumpitak C, Birkmann E 
    Kinetics of AGE-formation on BSA with various reducing sugars and dicarbonyl compounds in equimolar ratios 
    Rejuvenation Res. 15(2), 201-5 (2012) 
  • Matousek J, Riesner D, Steger G 
    Viroids: the smallest known infectious agents cause accumulation of viroid-specific small RNAs 
    In "From Nucleic Acids Sequences to Molecular Medicine" (Erdmann VA, Barciszewski J) Springer-Verlag, Heidelberg IX, 629-644 (2012)  
  • Matousek J, Stehlík J, Procházková J, Orctová L, Wullenweber J, Füssy Z, Kovácik J, Duraisamy GS, Ziegler A, Schubert J, Steger G 
    Biological and molecular analysis of the pathogenic variant C3 of potato spindle tuber viroid (PSTVd) evolved during adaptation to chamomile (Matricaria chamomilla) 
    Biol Chem 393, 605-615 (2012)  
  • Mazargui H, Lévêque C, Bartnik D, Fantini J, Gouget T, Melone MA, Funke SA, Willbold D, Perrone L 
    A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis. 
    Aging Cell 11, 530-541 (2012) 
  • Neudecker P, Robustelli P, Cavallli A, Walsh P, Lundstrom P, Zarrine-Afsar A, Sharpe S, Vendruscolo M, Kay LE 
    Structure of an intermediate state in protein folding and aggregation. 
    Science 336, 362-366 (2012) 
  • O'Donovan DJ, I Stokes-Rees, Y Nam, S Blacklow, GF Schröder, AT Brunger, Piotr Sliz 
    A grid-enabled web service for low-resolution crystal structure refinement. 
    Acta Cryst. D 68, 268 (2012) 
  • Rediger, A, Geißen, R, Steuten, B, Heilmann, B, Wagner, R and Axmann, I M 
    6S RNA – an old issue became blue-green. 
    Microbiology 158, 2480-2491 (2012) 
  • Singh S, Möckel L, Thiagarajan-Rosenkranz P, Wittlich M, Willbold D, Koenig B 
    Mapping the interaction between the cytoplasmic domains of HIV-1 VpU and human CD4 using NMR spectroscopy. 
    FEBS J. 279, 3705-3714 (2012) 
  • Steuten, B and Wagner, R 
    A conformational switch is responsible for the reversal of the 6S RNA-dependent RNA polymerase inhibition in Escherichia coli. 
    Biol. Chem. 393, 513–1522 (2012) 
  • Stratmann T, Pul U, Wurm R, Wagner R, Schnetz K 
    RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants 
    Mol. Microbiol. 83, 1109-1123 (2012) 
  • Sun N, Funke SA, Willbold D 
    A survey of peptides with effective therapeutic potential in Alzheimer’s disease rodent models or in human clinical studies. 
    Mini. Rev. Med. Chem. 12, 388-398 (2012) 
    full text open access  
  • Sun N, Funke SA, Willbold D 
    Mirror image phage display - Generating stable therapeutically and diagnostically active peptides with biotechnological means. 
    J. Biotech. 161, 121-125 (2012)  
    full text  
  • Sun N, Hartmann R, Lecher J, Stoldt M, Funke SA, Gremer L, Ludwig H-H, Demuth H-U, Kleinschmidt M, Willbold D 
    Structural analysis of the pyroglutamate modified isoform of the Alzheimer's disease related beta-amyloid using NMR spectroscopy. 
    J. Pept. Science 18, 691-695 (2012) 
  • T Sabir, A Toulmin, L Ma, AC Jones, P McGlynn, GF Schröder, and SW Magennis 
    Branchpoint expansion in a fully-complementary three-way DNA junction. 
    J. Am. Chem. Soc. 134(14), 6280 (2012) 
  • van Groen T, Kadish I, Funke A, Bartnik D, Willbold D 
    Treatment with Aβ42 Binding d-Amino Acid Peptides Reduce Amyloid Deposition and Inflammation in APP/PS1 Double Transgenic Mice. 
    Adv. Protein. Chem. Struct. Biol. 88, 133-152 (2012) 
  • Wagner R, Pul U 
    CRISPR - a bacterial immunity system based on small RNAs 
    In: From Nucleic Acids Sequences to Molecular Medicine, Erdmann, Volker A.; Barciszewski, Jan (Eds.), Springer-Verlag IX, 121-143 (2012) 
    full text  
  • Wang W, Pacheco V, Krause H-J, Zhang Y, Dong H, Hartmann R, Willbold D, Offenhaeusser A, Gu Z 
    Size and compositional effects on contrast efficiency of functionalized superparamagnetic nanoparticles at ultralow and ultrahigh magnetic fields. 
    J. Phys. Chem. C 116, 17880-17884 (2012)  
  • Wang Z, Schröder GF 
    Real-space Refinement with DireX: From Global Fitting to Side-chain Improvements. 
    Biopolymers 97(9), 687 (2012) 
  • X Yu, C Goforth, C Meyer, R Rachel, R Wirth, GF Schröder, and EH Egelman 
    Filaments from Ignicoccus hospitalis Show Diversity of Packing in Proteins Containing N-terminal Type IV Pilin Helices. 
    J. Mol. Biol. 422(2), 274 (2012) 
  • Ziegler A, Matousek J, Steger G, Schubert J 
    Complete sequence of a cryptic virus from hemp (Cannabis sativa) 
    Arch. Virol. 157, 383-385 (2012)  

Physikalische Biologie
Gebäude 26.12, Ebene U1
Universitätsstraße 1
40225 Düsseldorf

Prof. Dr. D. Willbold
Gebäude 26.12
Ebene U1, Raum 84
Telefon: +49-(0)211 / 81-11390
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