Publikationen in 2016

  • Alexander K. Buell 
    The nucleation of protein aggregates – from crystals to fibrils 
    International Review of Cell and Molecular Biology , (2016) 
    http://dx.doi.org/10.1016/bs.ircmb.2016.08.014  
  • Anđela Šarić, Alexander K. Buell, Georg Meisl, Thomas C. T. Michaels, Sara Linse, Tuomas P. J. Knowles and Daan Frenkel 
    Physical determinants for the self-replication of protein fibrils 
    Nature Physics 12, 874-880 (2016) 
    http://www.nature.com/nphys/journal/v12/n9/full/nphys3828.html  
  • Barz B and Strodel B 
    Understanding Amyloid-β oligomerization at the molecular level: the role of the fibril surface. 
    Chem. Eur. J. 22, 8768-8772 (2016) 
  • Bronder AM, Bieker A, Elter S, Etzkorn M, Haeussinger D, Oesterhelt F 
    Oriented membrane protein reconstitution into tethered lipid membranes for AFM Force Spectroscopy 
    Biophys. J. 111, 1925-1934 (2016) 
    http://dx.doi.org/10.1016/j.bpj.2016.08.051  
  • Carballo-Pacheco M and Strodel B 
    Advances in the Simulation of Protein Aggregation at the Atomistic Scale 
    J. Phys. Chem. B 120, 2991–2999 (2016) 
  • Céline Galvagnion, James Brown, Myriam M. Ouberai, Patrick Flagmeier, Michele Vendruscolo, Alexander K. Buell, Emma Sparr and Christopher M. Dobson 
    The chemical properties of lipids strongly affect the rate of the nucleation step in the membrane-induced aggregation of α-synuclein 
    PNAS 113(26), 7065-7070 (2016) 
    http://www.pnas.org/content/113/26/7065  
  • Dammers C, Yolcu D, Kukuk L, Willbold D, Pickhardt M, Mandelkow E, Horn AH, Sticht H, Malhis MN, Will N, Schuster J, Funke SA. 
    Selection and characterization of Tau binding D-enantiomeric peptides with potential for therapy of Alzheimer disease 
    PLoS One 11, e0167432 , (2016) 
    http://dx.doi.org/10.1371/journal.pone.0167432  
  • Della Corte D, Wildberg A, Schröder GF 
    Protein Structure Refinement with Adaptively Restrained Homologous Replicas  
    Proteins , (2016) 
    https://doi.org/10.1002/prot.24939  
  • Dick M, Hartmann R, Weiergräber OH, Bisterfeld C, Classen T, Schwarten M, Neudecker P, Willbold D, Pietruszka J. 
    Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies. 
    Chem. Sci. 7, 4492-4502 (2016) 
  • Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg LU, Lothmann K,Rizzi F, Schaller M, Gohlke H, Willbold D, Grenegard M, Elvers M. 
    Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release 
    Sci Signal 9(429), ra52 (2016) 
    http://10.1126/scisignal.aaf6240  
    http://stke.sciencemag.org/content/9/429/ra52.long  
  • Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Christopher M. Dobson, Clemens F. Kaminski, Gabriele S. Kaminski Schierle 
    Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons 
    PNAS 113(14), 3815-3819 (2016) 
    http://www.pnas.org/content/113/14/3815  
  • Giulio Costantini, Zoe Budrikis, Alessandro Taloni, Alexander K. Buell, Stefano Zapperi and Caterina A.M. La Porta 
    Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease 
    Phys Rev Appl 6, 034012 (2016) 
    http://journals.aps.org/prapplied/abstract/10.1103/PhysRevApplied.6.034012  
  • Hülsemann M, Zafiu C, Kühbach K, Lühmann N, Herrmann Y, Peters L, Linnartz C, Willbold J, Kravchenko K, Kulawik A, Willbold S, Bannach O, Willbold D.  
    Biofunctionalized Silica Nanoparticles: Standards in Amyloid-β Oligomer-Based Diagnosis of Alzheimer's Disease. 
    J. Alzheimers Dis. 54, 79-88 (2016) 
    https://dx.doi.org/10.3233/JAD-160253  
    http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160253  
  • James Brown, Alexander K. Buell, Thomas C.T. Michaels, Georg Meisl, Jackie Carozza, Patrick Flagmeier, Michele Vendruscolo, Tuomas P.J. Knowles, Christopher M. Dobson, Céline Galvagnion 
    β-synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding 
    Scientific Reports 6, 36010 (2016) 
    http://www.nature.com/articles/srep36010  
  • Jiang N, Frenzel D, Schartmann E, van Groen T, Kadish I, Shah NJ, Langen KJ, Willbold D, Willuweit A. 
    Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, D-enantiomeric peptide 
    BBA Biomembranes 1858, 2717-2724 (2016) 
  • Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D. 
    Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. 
    PLoS One 11(4), (2016) 
    http://dx.doi.org/10.1371/journal.pone.0153035  
    Erratum in: PLoS One. 2016;11(7):e0158960. http://dx.doi.org/10.1371/journal.pone.0158960 
  • Klionsky DJ, et al, Schwarten M, et al, Willbold D, et al (many co-authors) 
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 
    Autophagy 12, 1-222 (2016) 
    http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1100356  
  • Koch K, Hartmann R, Schröter F, Suwala AK, Maciaczyk D, Krüger AC, Willbold D, Kahlert UD, Maciaczyk J.  
    Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells.  
    Oncotarget , (2016) 
  • Kovacic F, Bleffert F, Caliskan M, Wilhelm S, Granzin J, Batra-Safferling R, Jaeger KE. 
    A membrane-bound esterase PA2949 from Pseudomonas aeruginosa is expressed and purified from Escherichia coli. 
    FEBS Open Bio. Apr 19;6(5), 484-93 (2016) 
    http://dx.doi.org/10.1002/2211-5463.12061  
    http://www.ncbi.nlm.nih.gov/pubmed/27419054  
  • Kovacic F, Mandrysch A, Poojari C, Strodel B, Jaeger KE 
    Structural features determining thermal adaptation of esterases 
    Protein Eng. Des. Sel. 29, 65-76 (2016) 
  • Krichel C, Weiergräber OH, Pavlidou M, Mohrlüder J, Schwarten M, Willbold D, Neudecker P. 
    Sequence-specific 1H, 15N, and 13C resonance assignments of the autophagy-related protein LC3C 
    Biomol NMR Assign 10, 41-43 (2016) 
  • Kühbach K, Hülsemann M, Herrmann Y, Kravchenko K, Kulawik A, Linnartz C, Peters L, Wang K, Willbold J, Willbold D, Bannach O. 
    Application of an Amyloid Beta Oligomer Standard in the sFIDA Assay 
    Front. Neurosci. 10:8, (2016) 
    http://dx.doi.org/10.3389/fnins.2016.00008  
    http://journal.frontiersin.org/article/10.3389/fnins.2016.00008  
  • Kynast P, Derreumaux P and Strodel B 
    Evaluation of the coarse-grained OPEP force field for protein-protein docking 
    BMC Biophysics 9, 4 (2016) 
  • Leithold LH, Jiang N, Post J, Niemietz N, Schartmann E, Ziehm T, Kutzsche J, Shah NJ, Breitkreutz J, Langen KJ, Willuweit A, Willbold D.  
    Pharmacokinetic properties of tandem D-peptides designed for treatment of Alzheimer's disease 
    Eur. J. Pharm. Sci. 89, 31-38 (2016) 
    http://dx.doi.org/10.1016/j.ejps.2016.04.016  
  • Leithold LH, Jiang N, Post J, Ziehm T, Schartmann E, Kutzsche J, Shah NJ, Breitkreutz J, Langen KJ, Willuweit A, Willbold D. 
    Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers 
    Pharm Res. 33, 328-336 (2016) 
  • Luczak SE, Smits SH, Decker C, Nagel-Steger L, Schmitt L, Hegemann JH 
    The Chlamydia pneumoniae Adhesin Pmp21 Forms Oligomers with Adhesive Properties. 
    J Biol Chem 291(43), 22806-22818 (2016) 
    http://doi.10.1074/jbc.M116.728915  
    http://www.jbc.org/content/291/43/22806  
  • Lühmann N, Niu A, Allgaier J, Stellbrink J, Zorn R, Linnolahti M, Willbold S, Koenig BW, Grillo I, Richter D, Fetters LJ. 
    The initiation mechanism of butadiene polymerization in aliphatic hydrocarbons: A full mechanistic approach.  
    Macromolecules 49, 5397-5406 (2016) 
    http://doi.org/10.1021/acs.macromol.6b01115  
  • Manuel Wolff, Judith J. Mittag, Therese W. Herling, Erwin De Genst, Christopher M. Dobson, Tuomas P.J. Knowles, Dieter Braun and Alexander K. Buell 
    Quantitative thermophoretic study of disease-related protein aggregates 
    Scientific Reports 6, 22829 (2016) 
    http://www.nature.com/articles/srep22829  
  • Mirecka EA, Feuerstein S, Gremer L, Schröder GF, Stoldt M, Willbold D, Hoyer W. 
    β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor 
    Scientific Reports 6, 33474 (2016) 
    https://dx.doi.org/10.1038/srep33474  
    http://www.nature.com/articles/srep33474  
  • Nagel-Steger L, Owen MC, and Strodel B 
    An account of amyloid oligomers: facts and figures obtained from experiments and simulations 
    ChemBioChem 17, 657-676 (2016) 
    http://dx.doi.org/10.1002/cbic.201500623  
  • Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR. 
    IQGAP1 interaction with RHO family proteins revisited: Kinetic and equilibrium evidence for multiple distinct binding sites 
    J Biol Chem , (2016) 
    http://10.1074/jbc.M116.752121  
    http://www.jbc.org/content/early/2016/11/04/jbc.M116.752121.abstract  
    [Epub ahead of print] 
  • Orr AA, Wördehoff MM, Hoyer W, Tamamis P 
    Uncovering the binding and specificity of β-wrapins for amyloid-β and α-synuclein 
    Journal of Physical Chemistry B 120, 12781-12794 (2016) 
    https://dx.doi.org/10.1021/acs.jpcb.6b08485  
  • Owen MC, Strodel B, Csizmadia IG & Viskolcz B 
    Radical Formation Initiates Solvent-Dependent Unfolding and β-Sheet Formation in a Model Helical Peptide 
    J. Phys. Chem. B 120, 4878-4889 (2016) 
  • Panwalkar V, Neudecker P, Schmitz M, Lecher J, Schulte M, Medini K, Stoldt M, Brimble MA, Willbold D, Dingley AJ. 
    The Nedd4-1 WW Domain Recognizes the PY Motif Peptide through Coupled Folding and Binding Equilibria 
    Biochemistry 55, 659-674 (2016) 
    http://pubs.acs.org/doi/full/10.1021/acs.biochem.5b01028  
  • Panwalkar V, Schulte M, Lecher J, Stoldt M, Willbold D, Dingley AJ 
    Data describing the solution structure of the WW3* domain from human Nedd4-1 
    Data Brief 22;8, 605-12 (2016) 
    http://dx.doi.org/10.1016/j.dib.2016.06.024  
    https://www.ncbi.nlm.nih.gov/pubmed/27419198  
  • Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas PJ Knowles, Christopher M. Dobson, Alexander K. Buell and Céline Galvagnion 
    Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein amyloid formation 
    PNAS 113(37), 10328-10333 (2016) 
    http://www.pnas.org/content/113/37/10328  
  • Röllen K, Granzin J, Panwalkar V, Arinkin V, Rani R, Hartmann R, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R. 
    Signaling States of a Short Blue-Light Photoreceptor Protein PpSB1-LOV Revealed from Crystal Structures and Solution NMR Spectroscopy. 
    J Mol Biol. 428, 3721 - 3736 (2016) 
    http://dx.doi.org/10.1016/j.jmb.2016.05.027  
    http://www.ncbi.nlm.nih.gov/pubmed/27291287  
  • Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C,Gremer L, Funke SA, Kutzsche J, Willbold D. 
    Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity 
    PLoS One 11(7), (2016) 
    http://dx.doi.org/10.1371/journal.pone.0159470  
    http://journals.plos.org/plosone/article?id=info:doi/10.1371/journal.pone.0159470  
  • Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C, Gremer L, Funke SA, Kutzsche J, Willbold D.  
    Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity. 
    PLoS One 11(2):e0147470., (2016) 
    http://dx.doi.org/10.1371/journal.pone.0147470  
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147470  
  • Steger G, Perreault JP 
    Structure and associated biological functions of viroids 
    Adv. Virus Res. 94, 141-172 (2016) 
    http://dx.doi.org/10.1016/bs.aivir.2015.11.002  
  • Streich C, Akkari L, Decker C, Bormann J, Rehbock C, Müller-Schiffmann A, Niemeyer FC, Nagel-Steger L, Willbold D, Sacca B, Korth C, Schrader T, Barcikowski S.  
    Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation. 
    ACS Nano 10, 7582-7597 (2016) 
    http://dx.doi.org10.1021/acsnano.6b02627  
  • Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, EzzahoiniH, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP 
    The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner 
    J Biol Chem 289(1), 74-88 (2016) 
    http://dx.doi.org/10.1074/jbc.M113.532333  
    http://www.jbc.org/content/289/1/74.long  
  • Thomaier M, Gremer L, Dammers C, Fabig J, Neudecker P, Willbold D. 
    High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs 
    Biochemistry , (2016) 
    http://dx.doi.org/10.1021/acs.biochem.6b00829  
    http://pubs.acs.org/doi/ipdf/10.1021/acs.biochem.6b00829  
  • Thomas O. Mason, Thomas C.T. Michaels, Aviad Levin, Ehud Gazit, Christopher M. Dobson, Alexander K. Buell and Tuomas P. J. Knowles 
    Synthesis of non-equilibrium supra-molecular peptide polymers on a microfluidic platform 
    JACS 138(30), 9589-9596 (2016) 
    http://pubs.acs.org/doi/abs/10.1021/jacs.6b04136  
  • Týcová A, Piernikarczyk RJJ, Kugler M, Lipovová P, Podzimek T, Steger G, Matoušek J 
    A 5'P degradation hot spot influences molecular farming of anticancerogenic nuclease TBN1 in tobacco cells. 
    Plant Cell Tiss Organ Cult 127, 347-358 (2016) 
    http://dx.doi.org/10.1007/s11240-016-1054-x  
  • Viegas A, Viennet T, Etzkorn M 
    The power, pitfalls and potential of the nanodisc system for NMR-based studies  
    Biol. Chem. 397, 1335–1354 (2016) 
    https://doi.org/10.1515/hsz-2016-0224  
  • Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M 
    UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. 
    J. Biomol. NMR 64, 9-15 (2016) 
    http://dx.doi.org/10.1007/s10858-015-0008-7  
  • Viennet T, Viegas A, Kuepper A, Arens S, Gelev V, Petrov O, Grossmann TN, Heise H, Etzkorn M 
    Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization 
    Angew. Chem. Int. Ed. 55, 10746–10750 (2016) 
    http://dx.doi.org/10.1002/anie.201603205  
    (selected as inside cover article)  
  • Wallin C, Kulkarni YS, Abelein A, Jarvet J, Liao Q, Strodel B, Olsson L, Luo J, Abrahams JP, Sholts SB, Roos PM, Kamerlin SCL, Gräslund A, Wärmländer SKTS 
    Characterization of Mn(II) ion Binding to the Amyloid-β Peptide in Alzheimer’s Disease 
    J Trace Elem Med Biol , (2016) 
    http://www.sciencedirect.com/science/article/pii/S0946672X1630030X  
  • Wang W, Ma P, Dong H, Krause HJ, Zhang Y, Willbold D, Offenhaeusser A, Gu Z A. 
    A magnetic nanoparticles relaxation sensor for protein-protein interaction detection at ultra-low magnetic field.  
    Biosens. Bioelectron. 80, 661-665 (2016) 
    http://dx.doi.org/10.1016/j.bios.2016.02.037  
  • Weirich F, Gremer L, Mirecka EA, Schiefer S, Hoyer W, Heise H 
    Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core 
    PLOS One 11, e0161243 (2016) 
    http://dx.doi.org/10.1371/journal.pone.0161243  
  • Yingbo Zhang, Alexander K. Buell, Thomas Müller, Erwin De Genst, Justin Benesch, Christopher M. Dobson and Tuomas P. J. Knowles 
    Protein aggregate-ligand binding assays based on microfluidic diffusional separation 
    ChemBioChem 17(20), 1920-1924 (2016) 
    http://onlinelibrary.wiley.com/doi/10.1002/cbic.201600384/abstract  
  • Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E,Nürnberg B, Ahmadian MR 
    Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1 
    PLoS One 9(7), (2016) 
    http://dx.doi.org/10.1371/journal.pone.0102425  
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102425  
  • Zhang-Haagen B, Biehl R, Nagel-Steger L, Radulescu A, Richter D, Willbold D. 
    Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering. 
    PLoS One 11(2), e0150267 (2016) 
    http://dx.doi.org/10.1371/journal.pone.0150267  
  • Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D. 
    Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species. 
    ACS Chem Neurosci. 7 (8), 1088–1096 (2016) 
    http://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00047  

Physikalische Biologie
Heinrich-Heine-Universität
Gebäude 26.12, Ebene U1
Universitätsstraße 1
40225 Düsseldorf
Deutschland

Institutsleitung
Prof. Dr. D. Willbold
Gebäude 26.12
Ebene U1, Raum 84
Telefon: +49-(0)211 / 81-11390
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