Program: Second Düsseldorf-Jülich Symposium on Neurodegenerative Diseases
Monday, November 27, 2017
9:00 | Registration |
| 9:30 | WELCOME Chair: Dieter Willbold, Heinrich Heine University Düsseldorf/Forschungszentrum Jülich |
9:30 | Anja Steinbeck (President of the Heinrich Heine University Düsseldorf) Opening address |
9:45 | Thomas van Groen (Dept. Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA) Alzheimer's (?) disease: a history |
10:30 | Coffee break |
11:00 | SESSION 1: Abeta formation and elimination mechanisms Chair: Alexander Büll, Heinrich Heine University Düsseldorf |
11:00 | Stefan Lichtenthaler (Neuroproteomik, Technische Universität München and German Center for Neurodegenerative Diseases (DZNE) München, Germany) Secretases as drug targets in Alzheimer’s disease |
11:50 | Christian Haass (Laboratory of Neurodegenerative Disease Research LMU München and German Center for Neurodegenerative Diseases (DZNE) München, Germany) TREM2 – from microglial dysfunction to human patients |
12:40 | Stephan Schilling (Fraunhofer Institute for Cell Therapy and Immunology, Department of Molecular Drug Design and Target Validation, Halle (Saale), Germany) Targeting Post-translationally modified Aβ: A Differential Approach of Passive Immunotherapy Oral presentation chosen from the poster abstracts |
13:00 | Lunch break |
| 13:45 | Gunnar Schröder (Institute of Complex Systems (ICS-6), Forschungszentrum Jülich, Germany/Physics Department, Heinrich-Heine-Universität, Germany) Structure Determination of Amyloid-β Fibrils by Cryo-EM Oral presentation chosen from the poster abstracts |
14:05 | Dieter Willbold (Institut für Physikalische Biologie, HHU Düsseldorf and Institute of Complex Systems (ICS), ICS-6: Structural Biochemistry , Forschungszentrum Jülich)
Direct and specific Aβ oligomer elimination enhances cognition and decelerates neurodegeneration |
14:35 | Roxana Carare (Clinical Neuroanatomy, Faculty of Medicine, University of Southampton, UK) |
15:25 | Coffee break |
15:55 | SESSION 2: Genetics of neurodegenerative diseases Chair: Wolfgang Hoyer, Heinrich Heine University Düsseldorf |
15:55 | Christine Van Broeckhoven (VIB Center for Molecular Neurology & Institute Born-Bunge, University of Antwerp, Belgium |
16:45 | Lars Bertram (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Germany and School of Public Health, Imperial College, London, UK) The genetics of Alzheimer’s disease: from GWAS to NGS and beyond |
17:35 | Andreas Müller-Schiffmann (Department Neuropathology, Heinrich-Heine University, Düsseldorf, Germany) A common upstream target? Novel drug-like small molecules decrease toxic Abeta species and tau phosphorylation Oral presentation chosen from the poster abstracts |
17:55 | Break |
19:00 | Public Lecture (in German) Location: Maxhaus, Düsseldorf historic city center |
19:00 | Public Lecture: Christian Haass (Laboratory of Neurodegenerative Disease Research LMU München and German Center for Neurodegenerative Diseases (DZNE) München, Germany) Alzheimer Krankheit –100 Jahre nach Alois Alzheimer: wo steht die Forschung |
Tuesday, November 28, 2017
9:30 | SESSION 2: Genetics of neurodegenerative diseases, continued Chair: Wolfgang Hoyer, Heinrich Heine University Düsseldorf |
9:30 | John Hardy (Reta Lilla Weston Research Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK) Genomics and aetiology of Parkinson’s Disease |
10:20 | Antje Willuweit (Institute of Neuroscience and Medicine, Medical Imaging Physics, Forschungszentrum Jülich, Germany) Progressive Amyloid Load in the Brains of Transgenic Alzheimer´s Disease Mice Detected by Florbetaben PET Oral presentation chosen from the poster abstracts |
10:40 | Coffee break |
11:00 | SESSION 3: ApoE, cholesterol and statins Chair: Inga Kadish, University of Alabama at Birmingham, AL, USA |
11:00 | Tobias Hartmann (Deutsches Institut für Demenzprävention (DIDP), Experimental Neurology, Saarland University, Germany) LipiDiDiet – Lipid Based Multi-Nutrient Intervention in Pre-Dementia Alzheimer’s Disease, from Molecular Mechanisms to Disease Modifying Treatment |
11:50 | Benjamin Wolozin (Department of Pharmacology, School of Medicine, Pharmacology and Experimental Therapeutics, Boston University, USA) Membrane-less organelles and neurodegeneration: The biological underpinnings of neurodegeneration |
12:40 | SESSION 4: Mechanisms of seed formation and propagation Chair: Oliver Bannach, Forschungszentrum Jülich |
12:40 | Alexander K. Buell (Institut für Physikalische Biologie, Heinrich-Heine University, Düsseldorf, Germany) Novel insight into the mechanism of aggregation of α-synuclein Oral presentation chosen from the poster abstracts |
13:00 | Lunch break |
13:45 | Karen Duff (Department of Pathology and Cell Biology, Columbia University, New York, USA) Propagation of pathological proteins: lessons learned from the tauopathies |
14:35 | Beat Meier (Laboratory of Physical Chemistry, ETH Zurich, Switzerland) NMR atomic-resolution structures of Aβ |
15:25 | Anselm Horn (Bioinformatik, Institut für Biochemie, Emil-Fischer-Centrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany) Role of Amyloid-β's N-Terminus for the Stability of a Triple-Fibril Elucidated by Molecular Dynamics Simulations Oral presentation chosen from the poster abstracts |
| 15:45 | Coffee break |
16:15 | Christopher Dobson (Department of Chemistry, University of Cambridge, UK) The kinetics and mechanism of protein misfolding, aggregation and amyloid formation |
17:05 | Nolwen Rey (Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, Michigan, USA) Long-term effects of the prion-like propagation of alpha-synucleinopathy in the brain of wild-type mice |
17:55 | Postersession with guided poster tour and finger-food dinner buffet |
Wednesday, November 29, 2017
9:30 | SESSION 5: Common mechanisms of neurodegeneration Chair: Janine Kutzsche, Forschungszentrum Jülich |
9:30 | Neil Cashman (Djavad Mowafaghian Centre for Brain Health at UBC Hospital and UBC Life Sciences Institute, Vancouver, Canada) Initiation, propagation and inhibition of SOD1 misfolding in amyotrophic lateral sclerosis |
10:20 | Eva-Maria Mandelkow (German Center for Neurodegenerative Diseases (DZNE) and CAESAR Research Center, Bonn, Germany) Synaptic degeneration in animal models of Tau pathology |
11:10 | Rubén Fernández-Busnadiego (Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany) Unravelling the structure of toxic protein aggregates in situ Oral presentation chosen from the poster abstracts |
11:30 | Lunch break |
12:00 | Dieder Moechars (Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Belgium) |
12:50 | Adriano Aguzzi (Universitätsspital Zürich, Institut für Neuropathologie, Zurich, Switzerland) The surprising biology of mammalian prions |
13:40 | Coffee break |
14:00 | Panel discussion Are there common mechanisms triggering neurodegenerative diseases? Do we need higher safety levels when working with tissue-derived and artificial proteins?
Panel members: |
15:00 | Poster prizes and goodbye |
With support by Joachim Herz Stiftung
