09:00

Registration

Welcome

10:00

Welcome addresses

Andrea Icks, Vice President for Research and Transfer, Heinrich Heine University Düsseldorf, Germany

Frauke Melchior, Member of the Board, Forschungszentrum Jülich GmbH, Germany

Michael Lorrain, Chairman Alzheimer Forschung Initiative e.V., Düsseldorf, Germany

Session I: Clinical aspects of neurodegeneration

10:15

“Molecular imaging of neurodegeneration”,

Alexander Drzezga, University Hospital Cologne, Germany

11:05

Coffee break

11:30

"CSF- and blood-based biomarkers for early diagnosis of Alzheimer´s disease",

Oliver Peters, Charité Berlin, Germany

12:20

“Anti-Amyloid Treatment Strategies”,

Timo Grimmer, Technical University of Munich, Germany

13:05

Lunch break

13:50

"Biomarkerstrategies for manifest and prodromal Parkinson`s disease",

Brit Mollenhauer, Paracelsus Elena-Clinic Kassel, Germany

14:40

"Function of the Pyroglutamate residue in Neurodegeneration, Inflammation and Periodontitis”,

Hans-Ulrich Demuth, PerioTrap Pharmaceuticals GmbH, Halle, Germany

15:30

Coffee break

16:00

"Diagnostic approaches for early and differential diagnosis of frontotemporal dementias and ALS",

Markus Otto, University Hospital Ulm, Germany 

16:50

"Analysis of ex vivo target engagement of Abeta-oligomer-eliminating compound RD2 in

Brain homogenates by sFIDA assay",

Bettina Kass, Forschungszentrum Jülich, Germany

Talk by early career scientist

17:10

AFI Funding Opportunities talk,

Dietmar Thal, KU Leuven, Belgium

Poster Session

17:30

Poster session following by „after Poster session Dinner“

Session II: Non-amyloid aspects of neurodegeneration

09:30

“Brain Health – What’s Flu Got to Do With It?”,

Martin Korte, TU Braunschweig, Germany

10:20

"Structural and biochemical studies of the role of p62/SQSTM1 in maintenance of cellular

homeostasis",

Siavash Mostafavi, Forschungszentrum Jülich, Germany

Talk by early career scientist

10:40

Coffee break

11:10

"Investigating isoform-specific functions of Tau under healthy and pathological conditions

using Tau-deficient hiPSC-derived cortical neurons",

Sarah Bachman, University Hospital Cologne and University of Cologne, Cologne, Germany

Talk by early career scientist

Session III: Molecular aspects of protein aggregation

11:30

"Endo-lysosomal conditions trigger formation of Aβ oligomers that potently induce tau missorting",

Wolfgang Hoyer, Heinrich-Heine-University, Düsseldorf, Germany

12:50

„sFIDA - oligomer quantitation for pre-clinical and clinical R&D of CNS drugs”

Oliver Bannach, attyloid GmbH, Düsseldorf, Germany

13:10

Lunch break

14:00

“BACE1 substrates in Alzheimer’s disease – pharmacodynamic biomarkers or causes of side effects?”,

Stefan Lichtenthaler, German Center for Neurodegenerative Diseases, München, Germany

14:50

"Production and Structural Analysis of Amyloid Fibrils from Pyroglutamate Modified Amyloid β (3-42) by Solid-State NMR",

Luis Gardon, Forschungszentrum Jülich, Germany

Talk by early career scientist

15:10

Coffee break

15:40

“Alzheimer’s disease: a molecular view”,

Markus Zweckstetter, German Center for Neurodegenerative Diseases, Göttingen, Germany

16:30

“TDP-43 proteinopathies: Advances in understanding the molecular basis of clinical and pathological heterogeneity",

Manuela Neumann, University Hospital Tübingen, Germany

17:20

"Amyloid fibril structure of islet amyloid polypeptide by cryo-electron microscopy",

Tatsiana Kupreichyk, Forschungszentrum Jülich, Germany

Talk by early career scientist

Public lecture jointly organized with Alzheimer Forschung Initiative e.V. (AFI)

18:30

Admission to public lecture

„Alzheimer Früherkennung mit der iRIS Technologie – Hoffnung auf ein symptomfreies Altern“,

Prof. Dr. Klaus Gerwert, Ruhr-University Bochum, Germany

Session IV: Molecular and clinical Pathology

09:30

„Alzheimer’s disease: From amyloid to a multidimensional disease”,

Dietmar Thal, KU Leuven, Belgium

10:20

„The neuropathological and clinical picture of ALS: Initiation and propagation”,

Albert Ludolph, University Hospital Ulm, Germany“

11:10

Coffee break

11:40

“Small seeding-competent mutant huntingtin fibrils and their putative role in disease”,

Erich Wanker, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

12:30

"Alpha-synuclein seeds of Parkinson´s disease: Transmissible biological agents with prion-exceeding resistance to heat inactivation".

Michael Beekes, Robert Koch Institute, Berlin, Germany

13:20

Poster prize award, Linda Thienpont, AFI and closing remarks, Thomas van Groen and Dieter Willbold, organizing committee