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Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging
Eur J Pharm Sci 184:106421, (2023)
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- Maity D, Oh Y, Gremer L, Hoyer W, Magzoub M, Hamilton AD
Cucurbit[7]uril inhibits islet amyloid polypeptide aggregation by targeting N terminus hot segments and attenuates cytotoxicity
Chemistry , e202200456 (2022)
https://doi.org/10.1002/chem.202200456
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Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin
Nat Commun 13, 2363 (2022)
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All-d-Enantiomeric Peptide D3 Designed for Alzheimer’s Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors.
Journal of Medicinal Chemistry , (2021)
https://doi.org/10.1021/acs.jmedchem.1c00632
- König AS, Rösener NS, Gremer L, Tusche M, Flender D, Reinartz E, Hoyer W, Neudecker P, Willbold D, Heise H
Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy
J Biol Chem 296, 100499 (2021)
https://doi.org/10.1016/j.jbc.2021.100499
- Maity D, Kumar S, AlHussein R, Gremer L, Howarth M, Karpauskaite L, Hoyer W, Magzoubd M, Hamilton AD
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to antiamyloid agents
RSC Chem. Biol. 1, 225-232 (2020)
https://doi.org/10.1039/D0CB00086H
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Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils
Nat. Struct. Mol. Biol. 27, 660-667 (2020)
https://doi.org/10.1038/s41594-020-0442-4
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Clustering of human prion protein and α-synuclein oligomers requires the prion protein Nterminus
Commun. Biol. 3, 365 (2020)
https://doi.org/10.1038/s42003-020-1085-z
- Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D
Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication
J Biol Chem 294, 7388-7402 (2019)
https://doi.org/10.1074/jbc.RA119.007656
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Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy
Nat. Commun. 10, 3754 (2019)
https://doi.org/10.1038/s41467-019-11320-8
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Origin of metastable oligomers and their effects on amyloid fibril self-assembly
Chem. Sci. 9, 5937-5948 (2018)
https://doi.org/10.1039/c8sc01479e
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A d-enantiomeric peptide interferes with heteroassociation of amyloid-β oligomers and prion protein
J. Biol. Chem. 293, 15748-15764 (2018)
https://doi.org/10.1074/jbc.RA118.003116
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Pyroglutamate-modified amyloid-β(3-42) shows α-helical intermediates before amyloid formation.
Biophys. J. 112, 1621-1633 (2017)
- Elfgen A, Santiago-Schübel B, Gremer L, Kutzsche J, Willbold, D
Surprisingly high stability of the Aβ oligomer eliminating all-D-enantiomeric peptide D3 in media simulating the route of orally administered drugs
European Journal of Pharmaceutical Sciences 107, 203-207 (2017)
https://doi.org/10.1016/j.ejps.2017.07.015
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- Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RB, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF
Fibril structure of amyloid-ß(1-42) by cryoelectron microscopy
Science 358, 116-119 (2017)
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Optimization of D-peptides for Aβ monomer binding specificity enhances their potential to eliminate toxic Aβ oligomers
ACS Chem Neurosci 8, 1889-1900 (2017)
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The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.
Sci Rep. 7, 16275 (2017)
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Opposed effects of dityrosine formation in soluble and aggregated α-synuclein on fibril growth
J. Mol. Biol. 429, 3018-3030 (2017)
https://doi.org/10.1016/j.jmb.2017.09.005
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Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release
Sci Signal 9(429), ra52 (2016)
http://10.1126/scisignal.aaf6240
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Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination.
PLoS One 11(4), (2016)
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β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
Sci. Rep. 6, 33474 (2016)
https://dx.doi.org/10.1038/srep33474
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IQGAP1 interaction with RHO family proteins revisited: Kinetic and equilibrium evidence for multiple distinct binding sites
J Biol Chem , (2016)
http://10.1074/jbc.M116.752121
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Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
PLoS One 11(7), (2016)
http://dx.doi.org/10.1371/journal.pone.0159470
http://journals.plos.org/plosone/article?id=info:doi/10.1371/journal.pone.0159470
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Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity.
PLoS One 11(2):e0147470., (2016)
http://dx.doi.org/10.1371/journal.pone.0147470
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147470
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The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner
J Biol Chem 289(1), 74-88 (2016)
http://dx.doi.org/10.1074/jbc.M113.532333
http://www.jbc.org/content/289/1/74.long
- Thomaier M, Gremer L, Dammers C, Fabig J, Neudecker P, Willbold D.
High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs
Biochemistry , (2016)
http://dx.doi.org/10.1021/acs.biochem.6b00829
http://pubs.acs.org/doi/ipdf/10.1021/acs.biochem.6b00829
- Weirich F, Gremer L, Mirecka EA, Schiefer S, Hoyer W, Heise H
Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core
PLOS One 11, e0161243 (2016)
http://dx.doi.org/10.1371/journal.pone.0161243
- Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E,Nürnberg B, Ahmadian MR
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1
PLoS One 9(7), (2016)
http://dx.doi.org/10.1371/journal.pone.0102425
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102425
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Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.
ACS Chem Neurosci. 7 (8), 1088–1096 (2016)
http://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00047
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QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.
Sci Rep 5, 13222 (2015)
http://dx.doi.org/10.1038/srep13222
- Dammers C, Gremer L, Neudecker P, Demuth HU, Schwarten M, Willbold D
Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
PLoS One 10, e0139710 (2015)
- Dammers C, Gremer L, Reiß K, Klein AN, Neudecker P, Hartmann R, Sun N, Demuth HU, Schwarten M, Willbold D
Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol
PLoS One 10, e0143647 (2015)
- Jiang N, Leithold LH, Post J, Ziehm T, Mauler J, Gremer L, Cremer M, Schartmann E, Shah NJ, Kutzsche J, Langen KJ, Breitkreutz J, Willbold D, Willuweit A
Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease
PLoS One 10, e0128553 (2015)
- Gauhar A, Shaykhalishahi H, Gremer L, Mirecka EA, Hoyer W
Impact of subunit linkages in an engineered homodimeric binding protein to alpha-synuclein
Protein Eng. Des. Sel. 27, 473-479 (2014)
http://dx.doi.org/10.1093/protein/gzu047
- Mirecka EA, Gremer L, Schiefer S, Oesterhelt F, Stoldt M, Willbold D, Hoyer W
Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide
J. Biotechnol. 191, 221-227 (2014)
http://dx.doi.org/10.1016/j.jbiotec.2014.06.006
- Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR
Rho-kinase: regulation, (dys)function, and inhibition
Biol Chem. 394, 1399-1410 (2013)
full text
- Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division
Biol Chem 394, 1411-1423 (2013)
full text
- Sun N, Hartmann R, Lecher J, Stoldt M, Funke SA, Gremer L, Ludwig H-H, Demuth H-U, Kleinschmidt M, Willbold D
Structural analysis of the pyroglutamate modified isoform of the Alzheimer's disease related beta-amyloid using NMR spectroscopy.
J. Pept. Science 18, 691-695 (2012)
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