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Publications

  • Stadler AM, Granzin J, Cousin A, Batra-Safferling R. 
    Phosphorylated peptide of G protein-coupled receptor induces dimerization in activated arrestin. 
    Scientific Reports 10, 10938 (2020) 
    https://doi.org/10.1038/s41598-020-67944-0  
  • Bleffert F, Granzin J, Gohlke H, Batra-Safferling R, Jaeger KE, Kovacic F 
    Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization. 
    Acta Crystallography F75, 270-277 (2019) 
    https://doi.org/10.1107/S2053230X19002152  
    http://scripts.iucr.org/cgi-bin/paper?S2053230X19002152  
  • Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-RosenkranzP, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, PfefferK, Beer-Hammer S, Willbold D, Koenig BW 
    Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association 
    Scientific Reports 9, 54 (2019) 
    https://doi.org/10.1038/s41598-018-37185-3  
  • Lorenz C, Ince S, Zhang T, Cousin A, Batra-Safferling R, Nagel-Steger L, Herrmann C, Stadler AM. 
    Farnesylation of human guanylate-binding protein 1 as safety mechanism preventing structural rearrangements and uninduced dimerization. 
    FEBS J Epub ahead of print, Epub ahead of print (2019) 
    https://doi.org/10.1111/febs.15015  
    https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15015  
  • Fettweiss T, Röllen K, Granzin J, Reiners O, Endres S, Drepper T, Willbold D, Jaeger KE, Batra-Safferling R*, Krauss U* ( * corresponding authors) 
    Mechanistic Basis of the Fast Dark Recovery of the Short LOV Protein DsLOV from Dinoroseobacter shibae. 
    Biochemistry 57, 4833–4847 (2018) 
    http://dx.doi.org/10.1021/acs.biochem.8b00645  
  • Röllen, K.; Granzin, J.; Batra-Safferling, R*.; Stadler, A.M*. (* corresponding authors) 
    Small-angle X-ray scattering study of the kinetics of light-dark transition in a LOV protein 
    PLoS One 13(7):e0200746, (2018) 
    http://dx.doi.org/10.1371/journal.pone.0200746  
  • Arinkin V, Granzin J, Röllen K, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R. 
    Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools 
    Scientific Reports 7(42971), (2017) 
    http://dx.doi.org/10.1038/srep42971  
  • Batra-Safferling R and Granzin J.  
    The Structure of the Polar Core Mutant R175E and Its Functional Implications.  
    The Structural Basis Of Arrestin Functions, Vsevolod V. Gurevich (Editor); Springer International Publishing Chapter 11, 143-158 (2017) 
    ISBN: 978-3-319-57552-0 
  • Kovacic F, Bleffert F, Caliskan M, Wilhelm S, Granzin J, Batra-Safferling R, Jaeger KE. 
    A membrane-bound esterase PA2949 from Pseudomonas aeruginosa is expressed and purified from Escherichia coli. 
    FEBS Open Bio. Apr 19;6(5), 484-93 (2016) 
    http://dx.doi.org/10.1002/2211-5463.12061  
    http://www.ncbi.nlm.nih.gov/pubmed/27419054  
  • Röllen K, Granzin J, Panwalkar V, Arinkin V, Rani R, Hartmann R, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R. 
    Signaling States of a Short Blue-Light Photoreceptor Protein PpSB1-LOV Revealed from Crystal Structures and Solution NMR Spectroscopy. 
    J Mol Biol. 428, 3721 - 3736 (2016) 
    http://dx.doi.org/10.1016/j.jmb.2016.05.027  
    http://www.ncbi.nlm.nih.gov/pubmed/27291287  
  • Endres S, Granzin J, Circolone F, Stadler A, Krauss U, Drepper T, Svensson V, Knieps-Grünhagen E, Wirtz A, Cousin A, Tielen P, Willbold D, Jaeger K-E, Batra-Safferling R 
    Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae. 
    BMC Microbiology 15, 30 (2015) 
    http://www.biomedcentral.com/1471-2180/15/30  
  • Granzin J, Stadler A, Cousin A, Schlesinger R, Batra-Safferling R 
    Structural evidence for the role of polar core residue Arg175 in arrestin activation. 
    Scientific Reports 5, 15808 (2015) 
    http://dx.doi.org/10.1038/srep15808.  
    http://www.nature.com/articles/srep15808  
  • Eichhorn T, Winter D, Büchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet T, Granzin J, Efferth T 
    Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum. 
    Biochem Pharmacol. 85, 38-45 (2013) 
    http://dx.doi.org/10.1016/j.bcp.2012.10.006  
  • Kovacic F, Granzin J, Wilhelm S, Kojic-Prodic B, Batra-Safferling R, Jaeger KE 
    Structural and Functional Characterisation of TesA - A Novel Lysophospholipase A from Pseudomonas aeruginosa. 
    PLoS One 8, e69125 (2013) 
    http://dx.doi.org/10.1371/journal.pone.0069125  
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069125  
  • Circolone F, Granzin J, Jentzsch K, Drepper T, Jaeger K-E, Willbold D, Krauss U, Batra-Safferling R 
    Structural basis for the slow dark recovery of a full-length LOV protein from Pseudomonas putida. 
    J. Mol. Biol. 417, 362–374 (2012) 
  • Granzin J, Cousin A, Weirauch M, Schlesinger R, Büldt G, Batra-Safferling R 
    Crystal structure of p44, a constitutively active splice variant of visual arrestin. 
    J Mol Biol. 416(5), 611-8 (2012) 
    http://dx.doi.org/10.1016/j.jmb.2012.01.028  
  • Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergräber OH 
    Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain 
    Acta Cryst D68, 686-694 (2012) 
    http://dx.doi.org/10.1107/S0907444912008372  
  • Kirchberg K, Kim TY, Möller M, Skegro D, Dasara Raju G, Granzin J, Büldt G, Schlesinger R, Alexiev U 
    Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process. 
    Proc Natl Acad Sci U S A 108(46), 18690-5 (2011) 
    http://dx.doi.org/10.1073/pnas.1015461108  
  • Batra-Safferling R, Granzin J, Moedder S, Hoffmann S, Willbold D 
    Structural studies of PI3K SH3 domain in complex with a peptide ligand: Role of anchor residue in ligand binding. 
    Biol. Chem. 391, 33-42 (2010) 
  • Feuerstein SE, Pulvermüller A, Hartmann R, Granzin J, Stoldt M, Henklein P, Ernst OP, Heck M, Willbold D, Koenig BW 
    Helix formation in Arrestin accompanies recognition of photoactivated Rhodopsin. 
    Biochemsitry 48, 10733-42 (2009) 
  • Skegro D, Pulvermüller A, Krafft B, Granzin J, Hofmann KP, Büldt G, Schlesinger R 
    N-terminal and C-terminal domains of arrestin both contribute in binding to rhodopsin. 
    Photochem Photobiol. 83(2), 385-92 (2007) 
  • Batra-Safferling R, Abaraca-Heidemann K, Körschen HG, Tziatzios C, Stoldt M, Budyak I, Willbold D, Schwalbe H, Klein-Seetharaman J, Kaupp UB 
    Glutamic acid-rich proteins of rod photoreceptors are natively unfolded. 
    J Biol Chem 281, 1449-1460 (2006) 
  • Granzin J, Eckhoff A, Weiergräber OH 
    Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters 
    J Mol Biol 364, 799-809 (2006) 
  • Weiergräber OH, Eckhoff A, Granzin J 
    Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters 
    FEBS Lett 580, 251-255 (2006) 
  • Weiergräber OH, Senin II, Zernii EY, Churumova VA, Kovaleva NA, Nazipova AA, Permyakov SE, Permyakov EA, Philippov PP, Granzin J, Koch KW 
    Tuning of a neuronal calcium sensor 
    J Biol Chem 281, 37594-37602 (2006) 
  • Eckhoff A, Granzin J, Kamphausen T, Büldt G, Schulz B, Weiergräber OH 
    Crystallization and preliminary X-ray analysis of immunophilin-like FKBP42 from Arabidopsis thaliana 
    Acta Crystallogr F 61, 363-365 (2005) 
  • Khayat R, Batra R, Bebernitz GA, Olson MW, Tong L 
    Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods. 
    Biochemistry 43(2), 316-22 (2004) 
  • Choe HW, Park KS, Labahn J, Granzin J, Kim CJ, Büldt G 
    Crystallization and preliminary X-ray diffraction studies of alpha-cyclodextrin glucanotransferase isolated from Bacillus macerans. 
    Acta Crystallogr D Biol Crystallogr. 59(Pt 2), 348-9 (2003) 
  • Khayat R, Batra R, Qian C, Halmos T, Bailey M, Tong L 
    Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease. 
    Biochemistry 42(4), 885-91 (2003) 
  • Weiergräber OH, Senin II, Philippov PP, Granzin J, Koch KW 
    Impact of N-terminal myristoylation on the Ca2+-dependent conformational transition in recoverin 
    J Biol Chem 278, 22972-22979 (2003) 
  • Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L 
    Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase. 
    Proteins 49(2), 285-8 (2002) 
  • Gordeliy VI, Labahn J, Moukhametzianov R, Efremov R, Granzin J, Schlesinger R, Büldt G, Savopol T, Scheidig AJ, Klare JP, Engelhard M 
    Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex. 
    Nature 419(6906), 484-7 (2002) 
  • Labahn J, Neumann S, Büldt G, Kula MR, Granzin J 
    An alternative mechanism for amidase signature enzymes. 
    J Mol Biol. 322(5), 1053-64 (2002) 
  • Neumann S, Granzin J, Kula MR, Labahn J 
    Crystallization and preliminary X-ray data of the recombinant peptide amidase from Stenotrophomonas maltophilia. 
    Acta Crystallogr D Biol Crystallogr. 58(Pt 2), 333-5 (2002) 
  • Tsiavaliaris G, Fujita-Becker S, Batra R, Levitsky DI, Kull FJ, Geeves MA, Manstein DJ 
    Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium. 
    EMBO Rep. 3(11), 1099-105 (2002) 
  • Batra R, Khayat R, Tong L 
    Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. 
    Nature Struct Biol. 8(9), 810-7 (2001) 
  • Batra R, Khayat R, Tong L 
    Structural studies of herpesvirus proteases 
    Protein and Peptide Letters 8(5), 333-342 (2001) 
    http://dx.doi.org/10.2174/0929866013409229  
  • Khayat R, Batra R, Massariol MJ, Lagacé L, Tong L 
    Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease. 
    Biochemistry 40(21), 6344-51 (2001) 
  • Yang Z, Batra R, Floyd DL, Hung HC, Chang GG, Tong L 
    Potent and competitive inhibition of malic enzymes by lanthanide ions. 
    Biochem Biophys Res Commun 2;274(2), 440-4 (2000) 
  • Batra R, Geeves MA, Manstein DJ 
    Kinetic analysis of Dictyostelium discoideum myosin motor domains with glycine-to-alanine mutations in the reactive thiol region. 
    Biochemistry 38(19), 6126-34 (1999) 
  • Batra R, Manstein DJ 
    Functional characterisation of Dictyostelium myosin II with conserved tryptophanyl residue 501 mutated to tyrosine 
    Biol Chem. 380(7-8), 1017-23 (1999) 
  • Tyagi R, Batra R, Gupta MN 
    Amorphous enzyme aggregates: Stability toward heat and aqueous-organic cosolvent mixtures 
    Enzyme and Microbial Technology 24(5-6), 348-354 (1999) 
  • Van Dijk J, Furch M, Derancourt J, Batra R, Knetsch ML, Manstein DJ, Chaussepied P 
    Differences in the ionic interaction of actin with the motor domains of nonmuscle and muscle myosin II. 
    Eur J Biochem 260(3), 672-83 (1999) 
  • Granzin J, Wilden U, Choe HW, Labahn J, Krafft B, Büldt G 
    X-ray crystal structure of arrestin from bovine rod outer segments. 
    Nature 391(6670), 918-21 (1998) 
  • Schluckebier G, Labahn J, Granzin J, Saenger W 
    M.TaqI: possible catalysis via cation-pi interactions in N-specific DNA methyltransferases. 
    Biol Chem. 379(4-5), 389-400 (1998) 
  • Batra R, Tyagi R, Gupta MN 
    Influence of immobilization on enzyme activity in aqueous-organic cosolvent mixtures 
    Biocatalysis and Biotransformation 15(2), 101-119 (1997) 
  • Gupta MN, Batra R, Tyagi R, Sharma, A 
    Polarity index: The guiding solvent parameter for enzyme stability in aqueous-organic cosolvent mixtures 
    Biotechnology Progress 13(3), 284-288 (1997) 
  • Wilden U, Choe HW, Krafft B, Granzin J 
    Crystallization and preliminary X-ray analysis of arrestin from bovine rod outer segment. 
    FEBS Lett. 415(3), 268-70 (1997) 
  • Dong GQ, Batra R, Kaul R, Gupta MN, Mattiasson B 
    Alternative modes of precipitation of Eudragit S100: A potential ligand carrier for affinity precipitation of protein 
    Bioseparation 5(6), 339-350 (1995) 
  • Schluckebier G, Labahn J, Granzin J, Schildkraut I, Saenger W 
    A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase. 
    Gene 157(1-2), 131-4 (1995) 
  • Batra R, Gupta MN 
    Enhancement of Enzyme-Activity in Aqueous-Organic Solvent Mixtures 
    Biotechnology Letters 16(10), 1059-1064 (1994) 
  • Batra R, Gupta MN 
    Noncovalent Immobilization of Potato (Solanum-Tuberosum) Polyphenol Oxidase on Chitin 
    Biotechnology and Applied Biochemistry 19, 209-215 (1994) 
  • Cvak L, Jegorov A, Sedmera P, Havlicek V, Ondracek J, Husak M, Pakhomova S, Kratochvil B, Granzin J 
    Ergogaline, a New Ergot Alkaloid, Produced by Claviceps purpurea: Isolation, Identification, Crystal Structure and Molecular conformation. 
    J. Chem. Soc. PERKIN TRANS. 2, 1861-1865 (1994) 
  • Kumar A, Agarwal R, Batra R, Gupta MN 
    Effect of Polymer Concentration on Recovery of the Target Proteins in Precipitation Methods 
    Biotechnology Techniques 8(9), 651-654 (1994) 
  • Labahn J, Granzin J, Schluckebier G, Robinson DP, Jack WE, Schildkraut I, Saenger W 
    Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine. 
    Proc Natl Acad Sci U S A. 91(23), 10957-61 (1994) 
  • Schubert WD, Schluckebier G, Backmann J, Granzin J, Kisker C, Choe HW, Hahn U, Pfeil W, Saenger W 
    X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. 
    Eur J Biochem. 220(2), 527-34 (1994) 
  • Lenz A, Choe HW, Granzin J, Heinemann U, Saenger W 
    Three-dimensional structure of the ternary complex between ribonuclease T1, guanosine 3',5'-bisphosphate and inorganic phosphate at 0.19 nm resolution. 
    Eur J Biochem. 211(1-2), 311-6 (1993) 
  • Saenger W, Sandmann C, Theis K, Starikov EB, Kostrewa D, Labahn J, Granzin J 
    Structural and Functions Aspects of the DNA Binding Protein FIS; for Nucleic Acids and Molecular Biology. Edited by Fritz Eckstein and David M.J. Lilley. 
    Nucleic Acids and Molecular Biology Vol 7, Springer-Verlag. , (1993) 
  • Ding J, Choe HW, Granzin J, Saenger W 
    Structure of ribonuclease T1 complexed with zinc(II) at 1.8 A resolution: a Zn2+.6H2O.carboxylate clathrate. 
    Acta Crystallogr B. 48 ( Pt 2), 185-91 (1992) 
  • Granzin J, Puras-Lutzke R, Landt O, Grunert HP, Heinemann U, Saenger W, Hahn U 
    RNase T1 mutant Glu46Gln binds the inhibitors 2'GMP and 2'AMP at the 3' subsite. 
    J Mol Biol. 225(2), 533-42. (1992) 
  • Kostrewa D, Granzin J, Koch C, Choe HW, Raghunathan S, Wolf W, Labahn J, Kahmann R, Saenger W 
    Three-Dimensional Structure of The DNA Binding Protein FIS. 
    Structure & Function Vol. 2: Proteins. Eds. R.H. Sarma & M.H. Sarma, Adenine Press. , (1992) 
  • Kostrewa D, Granzin J, Stock D, Choe HW, Labahn J, Saenger W 
    Crystal structure of the factor for inversion stimulation FIS at 2.0 A resolution. 
    J Mol Biol. 226(1), 209-26 (1992) 
  • Keitel T, Granzin J, Simon O, Borriss R, Thomsen KK, Wessner H, Höhne W, Heinemann U 
    Crystallization of the hybrid Bacillus (1-3,1-4)-beta-glucanase H(A16-M). 
    J Mol Biol. 218(4), 703-4 (1991) 
  • Kostrewa D, Granzin J, Koch C, Choe HW, Raghunathan S, Wolf W, Labahn J, Kahmann R, Saenger W 
    Three-dimensional structure of the E. coli DNA-binding protein FIS. 
    Nature 349(6305), 178-80 (1991) 
  • Granzin J, Saenger W, Stolarski R, Shugar D 
    Solid State and Solution Structures of an Adenine Analogue of the Antiviral Acyclonucleoside 9- (1,3-Dihydroxy-2-propoxymethyl) guanine. 
    Z. Naturforsch 45c, 915-921 (1990) 
  • Weber H-J, Schulz M, Schmitz S, Granzin J, Siegert H 
    Determination and structural application of anisotropic bond polarisabilities in complex crystals. 
    J. Phys.: Condens. Matter 1, 8543-8557 (1989) 
  • Witt I, Witt HT, Di Fiore D, Röger M, Hinrichs W, Saenger W, Granzin J, Betzel C, Dauter Z 
    X-ray characterization of Single Crystals of the Reaction Center I of Water Splitting Photosysnthesis. 
    Ber. Bunsenges. Phys. Chem. 92, 1503-1506 (1988) 
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