- Agerschou ED, Schützmann MP, Reppert N, Wördehoff MM, Shaykhalishahi H, Buell AK, Hoyer W
β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation
Biophys. Chem. 269, 106519 (2021)
https://doi.org/10.1016/j.bpc.2020.106519
- Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenburger B, Hoyer W, Buell AK
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
eLife 8, e46112 (2019)
https://doi.org/10.7554/eLife.46112
- Falke M, Victor J, Wördehoff MM, Peduzzo A, Zhang T, Schröder GF, Buell AK, Hoyer W, Etzkorn M
α-Synuclein-derived lipoparticles in the study of α-synuclein amyloid fibril formation
Chem Phys Lipids 220, 57-65 (2019)
https://doi.org/10.1016/j.chemphyslip.2019.02.009
- Röder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schröder GF
Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy
Nat. Commun. 10, 3754 (2019)
https://doi.org/10.1038/s41467-019-11320-8
- Viennet T, Wördehoff MW, Uluca B, Poojari C, Shaykhalishahi H, Willbold D, Strodel B, Heise H, Buell AK, Hoyer W, Etzkorn M:
Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
Commun. Biol. 1, 44 (2018)
https://doi.org/10.1038/s42003-018-0049-z
- Dammers C, Schwarten M, Buell AK, Willbold D
Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways
Chem. Sci. 8, 4996-5004 (2017)
http://pubs.rsc.org/en/content/articlehtml/2017/sc/c6sc04797a
- Wördehoff M, Shaykhalishahi H, Groß L, Gremer L, Stoldt M, Buell AK, Willbold D, Hoyer W
Opposed effects of dityrosine formation in soluble and aggregated α-synuclein on fibril growth
J. Mol. Biol. 429, 3018-3030 (2017)
https://doi.org/10.1016/j.jmb.2017.09.005
http://www.sciencedirect.com/science/article/pii/S0022283617304278
- Alexander K. Buell
The nucleation of protein aggregates – from crystals to fibrils
International Review of Cell and Molecular Biology , (2016)
http://dx.doi.org/10.1016/bs.ircmb.2016.08.014
- Anđela Šarić, Alexander K. Buell, Georg Meisl, Thomas C. T. Michaels, Sara Linse, Tuomas P. J. Knowles and Daan Frenkel
Physical determinants for the self-replication of protein fibrils
Nature Physics 12, 874-880 (2016)
http://www.nature.com/nphys/journal/v12/n9/full/nphys3828.html
- Céline Galvagnion, James Brown, Myriam M. Ouberai, Patrick Flagmeier, Michele Vendruscolo, Alexander K. Buell, Emma Sparr and Christopher M. Dobson
The chemical properties of lipids strongly affect the rate of the nucleation step in the membrane-induced aggregation of α-synuclein
PNAS 113(26), 7065-7070 (2016)
http://www.pnas.org/content/113/26/7065
- Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Christopher M. Dobson, Clemens F. Kaminski, Gabriele S. Kaminski Schierle
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons
PNAS 113(14), 3815-3819 (2016)
http://www.pnas.org/content/113/14/3815
- Giulio Costantini, Zoe Budrikis, Alessandro Taloni, Alexander K. Buell, Stefano Zapperi and Caterina A.M. La Porta
Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease
Phys Rev Appl 6, 034012 (2016)
http://journals.aps.org/prapplied/abstract/10.1103/PhysRevApplied.6.034012
- James Brown, Alexander K. Buell, Thomas C.T. Michaels, Georg Meisl, Jackie Carozza, Patrick Flagmeier, Michele Vendruscolo, Tuomas P.J. Knowles, Christopher M. Dobson, Céline Galvagnion
β-synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding
Scientific Reports 6, 36010 (2016)
http://www.nature.com/articles/srep36010
- Manuel Wolff, Judith J. Mittag, Therese W. Herling, Erwin De Genst, Christopher M. Dobson, Tuomas P.J. Knowles, Dieter Braun and Alexander K. Buell
Quantitative thermophoretic study of disease-related protein aggregates
Scientific Reports 6, 22829 (2016)
http://www.nature.com/articles/srep22829
- Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas PJ Knowles, Christopher M. Dobson, Alexander K. Buell and Céline Galvagnion
Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein amyloid formation
PNAS 113(37), 10328-10333 (2016)
http://www.pnas.org/content/113/37/10328
- Thomas O. Mason, Thomas C.T. Michaels, Aviad Levin, Ehud Gazit, Christopher M. Dobson, Alexander K. Buell and Tuomas P. J. Knowles
Synthesis of non-equilibrium supra-molecular peptide polymers on a microfluidic platform
JACS 138(30), 9589-9596 (2016)
http://pubs.acs.org/doi/abs/10.1021/jacs.6b04136
- Yingbo Zhang, Alexander K. Buell, Thomas Müller, Erwin De Genst, Justin Benesch, Christopher M. Dobson and Tuomas P. J. Knowles
Protein aggregate-ligand binding assays based on microfluidic diffusional separation
ChemBioChem 17(20), 1920-1924 (2016)
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201600384/abstract
- Céline Galvagnion and Alexander K. Buell
Fundamental mechanisms of amyloid fibril formation by alpha-synuclein in Parkinson's disease: quantitative modelling
Med Sci (Paris) 31, 597-600 (2015)
http://www.medecinesciences.org/en/articles/medsci/abs/2015/07/medsci2015316-7p597/medsci2015316-7p597.html
- Céline Huynen, Nicolas Willet, Alexander K. Buell, Anne-Sophie Duwez, Christine Jerôme and Mireille Dumoulin
Influence of the protein context on the polyQ length dependent elongation rate of amyloid fibrils
Biochim. Biophys. Acta – Proteins & Proteomics 1854(3), 239-248 (2015)
http://www.sciencedirect.com/science/article/pii/S1570963914003185
- Galvagnion C, Buell AK, Meisl G, Michaels TCT, Vendruscolo M, Knowles TPJ and Dobson CM
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.
Nat. Chem. Biol. 11, 229-234 (2015)
Link to full text
- Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Dobson CM, Weitz DA and Knowles TPJ
Controlled structuring of protein-only amyloid nanofibril networks into 3D microgel particles
ACS Nano 9(1), 43-51 (2015)
Link to full text
- Thomas C.T. Michaels, Pernille Yde, Julian C.W. Willis, Mogens H. Jensen, Daniel E. Otzen, Christopher M. Dobson, Alexander K. Buell and Tuomas P.J. Knowles
The length distribution of frangible biofilaments
J Chem Phys 143, 164901 (2015)
http://aip.scitation.org/doi/abs/10.1063/1.4933230?journalCode=jcp
- Alexander K. Buell, Céline Galvagnion, Ricardo Gaspar, Emma Sparr, Michele Vendruscolo, Tuomas P.J. Knowles, Sara Linse and Christopher M. Dobson
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
PNAS 111(21), 7671-7676 (2014)
http://www.pnas.org/content/111/21/7671
- Alexander K. Buell, Christopher M. Dobson and Tuomas P.J. Knowles
The physical chemistry of the amyloid phenomenon - thermodynamics and kinetics of filamentous protein aggregation
Essays Biochem 56(1), 11-39 (2014)
http://essays.biochemistry.org/content/56/11
- Aviad Levin, Thomas Mason, Lihi Adler-Abramovich, Alexander K. Buell, Georg Meisl, Céline Galvagnion, Yaron Bram, Samuel A. Stratford, Christopher M. Dobson, Tuomas P.J. Knowles and Ehud Gazit
Ostwald's rule of stages governs structural transitions and morphological control of a dipeptide supramolecular polymer
Nature Communications 5, 5219 (2014)
http://www.nature.com/articles/ncomms6219
- Dorothea Pinotsi, Alexander K. Buell, Celine Galvagnion, Christopher M. Dobson, Gabriele S. Kaminski Schierle and Clemens F. Kaminski
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy
Nano Letters 14(1), 339-345 (2014)
http://pubs.acs.org/doi/abs/10.1021/nl4041093
- Nikolai Lorenzen, Søren Bang Nielsen, Alexander K. Buell, Jørn Døvling Kaspersen, Paolo Arosio, Brian Stougaard Vad, Gunna Christiansen, Zuzana Valnickova-Hansen, Maria Andreasen, Wojciech Paslawski, Jan J. Enghild, Christopher M. Dobson, Tuomas P. J. Knowles, Jan Skov Pedersen and Daniel Erik Otzen
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
JACS 136, 3859-3868 (2014)
http://pubs.acs.org/doi/abs/10.1021/ja411577t
- Samuel I. A. Cohen, Luke Rajah, Chang-Ho Yoon, Alexander K. Buell, Duncan A. White, Ralf A. Sperling, Michele Vendruscolo, Eugene M. Terentjev, Christopher M. Dobson, David A. Weitz and Tuomas P. J. Knowles
Spatial propagation of protein polymerisation
Physical Review Letters 12, 098101 (2014)
http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.112.098101
- Thomas C.T. Michaels, Alexander K. Buell, Eugene M. Terentjev and Tuomas P.J. Knowles
Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
J Phys Chem Lett 5, 695-699 (2014)
http://pubs.acs.org/doi/abs/10.1021/jz4024833
- Thomas O. Mason, Dimitri Y. Chirgadze, Aviad Levin, Lihi Adler-Abramovich, Ehud Gazit, Tuomas P.J. Knowles and Alexander K. Buell
Expanding the solvent chemical space for self-assembly of dipeptide nanostructures
ACS Nano 8, 1243-1253 (2014)
http://pubs.acs.org/doi/abs/10.1021/nn404237f
- Alexander K. Buell, Peter Hung, Xavier Salvatella, Mark E. Welland, Christopher M. Dobson and Tuomas P. J. Knowles
Electrostatic effects in filamentous protein aggregation
Biophysical Journal 104, 1116-1126 (2013)
http://www.cell.com/biophysj/abstract/S0006-3495(13)00136-7
- Andrea Pica, Antonello Merlino, Alexander K. Buell, Tuomas P.J. Knowles, Elio Pizzod, Giuseppe D'Alessio, Filomena Sica and Lelio Mazzarella
3D domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase
Acta Cryst. D 69, 2116-2123 (2013)
http://scripts.iucr.org/cgi-bin/paper?S0907444913020507
- Dorothea Pinotsi, Alexander K. Buell, Christopher M. Dobson, Gabriele S. Kaminski Schierle and Clemens F. Kaminski
A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence
ChemBioChem 14, 846-850 (2013)
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300103/abstract
- Li-Qiong Xu, Si Wu, Alexander K. Buell, Samuel I. A. Cohen, Li-Jun Chen, Wan-Hui Hu, Sarah A. Cusack, Laura S. Itzhaki, Hong Zhang, Tuomas P. J. Knowles, Christopher M. Dobson, Mark E. Welland, Gary W. Jones and Sarah Perrett
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2
Philos Trans R Soc Lond B Biol Sci 368, 20110410 (2013)
http://rstb.royalsocietypublishing.org/content/368/1617/20110410.long
- Tim Guilliams, Farah El-Turk, Alexander K. Buell, Elizabeth O'Day, Francesco Aprile, Elin K. Esbjörner, Michele Vendruscolo, Nunilo Cremades, Els Pardon, Lode Wyns, Mark E. Welland, Jan Steyaert, John Christodoulou, Christopher M. Dobson and Erwin De Genst
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
J Mol Biol 425, 2397-2411 (2013)
http://www.sciencedirect.com/science/article/pii/S0022283613001897
- Alexander K. Buell, Anne Dhulesia, Duncan A. White, Tuomas P.J. Knowles, Christopher M. Dobson, Mark E. Welland
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Angewandte Chemie Int Ed 51, 5247-5251 (2012)
http://onlinelibrary.wiley.com/doi/10.1002/anie.201108040/abstract
- Alexander K. Buell, Christopher M. Dobson, Mark E. Welland
Measuring the kinetics of amyloid fibril elongation using Quartz Crystal Microbalances (QCM)
Amyloid proteins - Methods and Protocols 849, 101-119 (2012)
http://link.springer.com/protocol/10.1007%2F978-1-61779-551-0_8
- Cintia Roodveldt, August Andersson, Erwin J. De Genst, Adahir Labrador-Garrido, Alexander K. Buell, Christopher M. Dobson, Gian Gaetano Tartaglia and Michele Vendruscolo
A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein
Biochemistry 51, 8771-8778 (2012)
http://pubs.acs.org/doi/abs/10.1021/bi300558q
- Alexander K. Buell, Anne Dhulesia (joint first authors), Maria F. Mossuto, Nunilo Cremades, Janet R. Kumita, Mireille Dumoulin, Mark E. Welland, Tuomas P. J. Knowles, Xavier Salvatella, Christopher M. Dobson
Population of non-native states of lysozyme mutants drives amyloid fibril formation
JACS 133, 7737-7743 (2011)
http://pubs.acs.org/doi/abs/10.1021/ja109620d
- Alexander K. Buell, Elin K. Esbjörner, Patrick J. Riss, Duncan A. White, Franklin I. Aigbirhio, Gergely Toth, Mark E. Welland, Christopher M. Dobson and Tuomas P.J. Knowles
Probing small molecule binding to amyloid fibrils
Phys Chem Chem Phys 13, 20044-20052 (2011)
https://www.ncbi.nlm.nih.gov/pubmed/22006124
- Sarah L. Shammas, Christopher A. Waudby, Shuyu Wang, Alexander K. Buell, Tuomas P.J. Knowles, Heath Ecroyd, Mark E. Welland, John A. Carver, Christopher M. Dobson and Sarah Meehan
Binding of the Molecular Chaperone alpha B-Crystallin to Abeta Amyloid Fibrils Inhibits Fibril Elongation
Biophysical Journal 101, 1681-1689 (2011)
https://www.ncbi.nlm.nih.gov/pubmed/21961594
- Yi-Qian Wang, Alexander K. Buell, Xin-Yu Wang, Mark E. Welland, Christopher M. Dobson, Tuomas P.J Knowles, Sarah Perrett
Relationship Between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly
J Biol Chem 286, 12101-12107 (2011)
http://www.jbc.org/content/286/14/12101.long
- Alexander K. Buell, Christopher M. Dobson, Tuomas P.J. Knowles and Mark E. Welland
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors
Biophysical Journal 99(10), 3492-3497 (2010)
http://www.cell.com/biophysj/references/S0006-3495(10)01108-2
- Alexander K. Buell, Duncan A. White, Christoph Meier, Mark E. Welland, Tuomas P.J. Knowles and Christopher M. Dobson
Surface attachment of protein fibrils via covalent modication strategies
J Phys Chem B 114, 10925-10938 (2010)
http://pubs.acs.org/doi/abs/10.1021/jp101579n
- Alexander K. Buell, Jamie R. Blundell, Christopher M. Dobson, Mark E. Welland, Eugene M. Terentjev and Tuomas P. J. Knowles
Frequency factors in a landscape model of filamentous protein aggregation
Physical Review Letters 104, 228101 (2010)
http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.228101
- Duncan A. White, Alexander K. Buell, Tuomas P.J. Knowles, Mark E. Welland and Christopher M. Dobson
Protein aggregation in crowded environments
JACS 132(14), 5170-5175 (2010)
http://pubs.acs.org/doi/abs/10.1021/ja909997e
- Tuomas P. J. Knowles, Tomas W. Oppenheim, Alexander K. Buell, Dimitri Y. Chirgadze and Mark E. Welland
Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
Nature Nanotechnology 5, 204-207 (2010)
http://www.nature.com/nnano/journal/v5/n3/abs/nnano.2010.26.html
- Alexander K. Buell, Gian Gaetano Tartaglia, Neil R. Birkett, Christopher A. Waudby, Michele Vendruscolo, Xavier Salvatella, Mark E. Welland, Christopher M. Dobson and Tuomas P.J. Knowles
Position dependent electrostatic protection against protein aggregation
ChemBioChem 10(8), 1309-1312 (2009)
http://onlinelibrary.wiley.com/doi/10.1002/cbic.200900144/abstract
- Duncan A. White, Alexander K. Buell, Christopher M. Dobson, Mark E. Welland and Tuomas P.J. Knowles
Biosensor-based label-free assays of amyloid growth
FEBS Lett 583(16), 2587-2592 (2009)
http://www.sciencedirect.com/science/article/pii/S0014579309004517
- W. Scott Hopkins, Hans-Peter Loock, Brid Cronin, Michael G. D. Nix, Adam L. Devine, Richard N. Dixon, Michael N. R. Ashfold, Hong-Ming Yin, Steven J. Rowling, Alexander Büll and Scott H. Kable
Quantitative (v, N, Ka ) product state distributions near the triplet threshold for the reaction H2CO → H + HCO measured by Rydberg tagging and laser-induced fluorescence
J Phys Chem A 112(39), 9283-9289 (2008)
http://pubs.acs.org/doi/abs/10.1021/jp8021826?src=recsys&journalCode=jpcafh
- Hong-Ming Yin, Steven J. Rowling, Alexander Büll and Scott H. Kable
Photodissociation dynamics of the reaction H2CO → H+HCO via the singlet (S0) and triplet (T1) surfaces
J Chem Phys 127(6), 064302 (2007)
http://aip.scitation.org/doi/abs/10.1063/1.2752161?journalCode=jcp
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