Chemical Biology of Protein Aggregation
Wolfgang Hoyer
The aggregation of proteins into amyloid fibril deposits is a pathological feature of various diseases, including nearly every major neurodegenerative disease such as Alzheimer and Parkinson. We are interested in the mechanism of amyloid formation, and investigate how it can be modulated.
ERC Consolidator project
BETACONTROL
Control of amyloid formation via β-hairpin molecular recognition features
News
- Sep. 2024: New paper in Cell Rep Phys Sci shows how a monomer binder can interfere with nucleation of amyloid fibrils: 2 minute video on the summary figure.
- Dec 2023: Two Heid et al. papers in Comput Struct Biol J and in Int J Mol Sci on beta-hairpin peptides that induce cross-amyloid aggregation
- Nov 2023: New paper in BBA Advances with click brick model how inhibitor and amyloid protein cooperate to block amyloid fibril ends
- May 2022: New paper The co-chaperonin prefoldin binds IAPP monomers and fibril surfaces, Nat Commun
- Dec 2021: Award for the best PhD thesis of the Faculty of Mathematics and Natural Sciences to Emil Dandanell Agerschou - Congratulations, Emil!
- November 2021: Tina Jacob has joined the group as PhD student
- July 2021: New paper Aβ oligomers preferentially form under endo-lysosomal conditions, Nat Commun; New insights into the formation of toxic protein clumps
- July 2021: New paper Beta-wrapin against α-synuclein inhibits fibril-induced aggregation in neurons, Front Neurosci
- Dec 2020: New paper High sequence identity required for amyloid fibril (cross-)elongation, Biophys Chem
- October 2020: New paper Metastable oligomers bind to amyloid fibril surfaces and inhibit secondary nucleation of fibrils, Angew Chem
- October 2020: New paper Inhibitor and substrate cooperate to inhibit amyloid fibril elongation, Chem Sci
- July 2020: New paper Clustering of prion protein and α-synuclein oligomers, Commun Biol
- June 2020: New paper Fibril structure of islet amyloid polypeptide, Nat Struct Mol Biol; New indication of a link between Alzheimer’s and diabetes; Alzforum: Does common structure explain cross-seeding of fibrils?