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Nanodiscs – Tool for membrane protein studies

Nanodiscs are self-assembled model membranes that resemble high density lipoprotein (HDL) particles. They consist of a small lipid bilayer patch and two copies of an amphipathic membrane scaffold protein (MSP) that shield the hydrophobic rim of the membrane fragment from water. Different scaffold proteins are in use, most popular are recombinantly produced variants of human apolipoprotein A-I. Nanodiscs have been optimized, promoted, and characterized in the laboratory of undefinedStephen G. Sligar at the University of Illinois at Urbana-Champaign.

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