Structural protein dynamics of IDPs

We aim to gain a deeper understanding of the structural dynamics of intrinsically disordered proteins (IDPs), covering a time range from picoseconds to milliseconds. Therefore, we employ state-of-the-art solution NMR and proton-detected solid-state NMR methods and improve them where needed.

Membrane interactions of IDPs

We study the membrane interactions of IDPs by combining solution NMR and proton-detected solid-state NMR. To access the lipid-bound conformation and transmembrane region of IDPs, we apply novel proton-detected solid-state NMR experiments based on fast magic angle spinning .

SNARE proteins in neuronal exocytosis

The release of neurotransmitters at the neuronal synapse is a crucial process for signal transmission between nerve cells. Our research focuses on the membrane-associated intrinsically disordered proteins (IDPs) that are pivotal in this process, particularly the SNARE proteins and their interaction partners.