- Amariei DA, Pozhydaieva N, David B, Schneider P, Classen T, Gohlke H, Weiergräber OH, Pietruszka J
Enzymatic C3-Methylation of Indoles Using Methyltransferase PsmD─Crystal Structure, Catalytic Mechanism, and Preparative Applications
ACS Catal 12, 14130-14139 (2022)
https://doi.org/10.1021/acscatal.2c04240
- Brown H, Chung M, Üffing A, Batistatou N, Tsang T, Doskocil S, Mao W, Willbold D, Bast RC Jr, Lu Z, Weiergräber OH, Kritzer JA
Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy
J Am Chem Soc 144, 14687-14697 (2022)
https://doi.org/10.1021/jacs.2c04699
- Huwa N, Weiergräber OH, Fejzagić AV, Kirsch C, Schaffrath U, Classen T
The Crystal Structure of the Defense Conferring Rice Protein OsJAC1 Reveals a Carbohydrate Binding Site on the Dirigent-like Domain
Biomolecules 12, 1126 (2022)
https://doi.org/10.3390/biom12081126
- Weiergräber OH, Petrović D, Kislat A, Pattky M, Fabig J, Batra-Safferling R, Schulte am Esch J, Hänel K, Huhn C, Strodel B, Homey B, Willbold D
Structure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity
Biomolecules 12, 1588 (2022)
https://doi.org/10.3390/biom12111588
- Cukkemane A, Becker N, Zielinski M, Frieg B, Lakomek NA, Heise H, SchröderGF, Willbold D, Weiergräber OH
Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses
Transl Psychiatry 11, 639 (2021)
https://doi.org/10.1038/s41398-021-01765-1
- Freischem S, Grimm I, López-Pérez A, Willbold D, Klenke B, Vuong C, DingleyAJ, Weiergräber OH
Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria
Biomolecules 11, 1057 (2021)
https://doi.org/10.3390/biom11071057
- Huwa N, Weiergräber OH, Kirsch C, Schaffrath U, Classen T
Biochemical and Initial Structural Characterization of the Monocot Chimeric Jacalin OsJAC1
Int J Mol Sci 22, 5639 (2021)
https://doi.org/10.3390/ijms22115639
- Klionsky DJ, et al, Schwarten M, et al, Weiergräber OH, et al, Willbold D, et al (many co-authors)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 17, 1-382 (2021)
https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280
- López-Pérez A, Freischem S, Grimm I, Weiergräber O, Dingley AJ, López-AlbercaMP, Waldmann H, Vollmer W, Kumar K, Vuong C
Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3
Antibiotics 10, 529 (2021)
https://doi.org/10.3390/antibiotics10050529
- Dobner J, Simons IM, Rufinatscha K, Hänsch S, Schwarten M, Weiergräber OH, Abdollahzadeh I, Gensch T, Bode JG, Hoffmann S, Willbold D.
Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-induced EGFR Degradation
Cells 9, 1296 (2020)
https://doi.org/10.3390/cells9051296
https://www.mdpi.com/2073-4409/9/5/1296
- Abdollahzadeh I, Hendriks J, Sanwald JL, Simons IM, Hoffmann S, Weiergräber OH, Willbold D, Gensch T
Autophagy-Related Proteins GABARAP and LC3B Label Structures of Similar Size but Different Shape in Super-Resolution Imaging
Molecules 24, E1833 (2019)
https://doi.org/10.3390/molecules24091833
- Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D
Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication
J Biol Chem 294, 7388-7402 (2019)
https://doi.org/10.1074/jbc.RA119.007656
- Krichel C, Möckel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergräber OH, Willbold D, Neudecker P
Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
Sci Rep 9, 14167 (2019)
https://doi.org/10.1038/s41598-019-48155-8
https://www.nature.com/articles/s41598-019-48155-8
- Schwarten M, Weiergräber OH, Petrović D, Strodel B, Willbold D
Structural Studies of Autophagy-Related Proteins
Methods Mol Biol 1880, 17-56 (2019)
https://link.springer.com/protocol/10.1007%2F978-1-4939-8873-0_2
- Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C
Biophysical insights from a single chain camelid antibody directed against the disrupted in schizophrenia 1 protein
PLoS One 13, e0191162 (2018)
- Abdollahzadeh I, Schwarten M, Gensch T, Willbold D, Weiergräber OH
The Atg8 Family of Proteins—Modulating Shape and Functionality of Autophagic Membranes
Front Genet 8, 109 (2017)
https://doi.org/10.3389/fgene.2017.00109
- Weiergräber OH, Schwarten M, Strodel B, Willbold D.
Investigating Structure and Dynamics of Atg8 Family Proteins.
Methods Enzymol 587, 115-142 (2017)
- Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C.
A structural organization for Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions which are bisected by mental illness related mutations.
J Biol Chem 292, 6468-6477 (2017)
http://dx.doi.org/10.1074/jbc.M116.773903
- Dick M, Hartmann R, Weiergräber OH, Bisterfeld C, Classen T, Schwarten M, Neudecker P, Willbold D, Pietruszka J.
Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies.
Chem. Sci. 7, 4492-4502 (2016)
- Dick M, Weiergräber OH, Classen T, Bisterfeld C, Bramski J, Gohlke H, Pietruszka J
Trading off stability against activity in extremophilic aldolases
Sci Rep 6, 17908 (2016)
- Krichel C, Weiergräber OH, Pavlidou M, Mohrlüder J, Schwarten M, Willbold D, Neudecker P
Sequence-specific 1H, 15N, and 13C resonance assignments of the autophagy-related protein LC3C
Biomol NMR Assign 10, 41-43 (2016)
- Pattky M, Barkovits K, Marcus K, Weiergräber OH, Huhn C
Statically Adsorbed Coatings for High Separation Efficiency and Resolution in CE-MS Peptide Analysis: Strategies and Implementation
Methods Mol Biol 1483, 53-75 (2016)
https://doi.org/10.1007/978-1-4939-6403-1_4
- Zhu J, Bailly A, Zwiewka M, Sovero V, Di Donato M, Ge P, Oehri J, Aryal B, Hao P, Linnert M, Burgardt NI, Lücke C, Weiwad M, Michel M, Weiergräber OH, Pollmann S, Azzarello E, Mancuso S, Ferro N, Fukao Y, Hoffmann C, Wedlich-Söldner R, Friml J, Thomas C, Geisler M
TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics
Plant Cell 28, 930-948 (2016)
https://doi.org/10.1105/tpc.15.00726
- Ma P, Schillinger O, Schwarten M, Lecher J, Hartmann R, Stoldt M, Mohrlüder J, Olubiyi O, Strodel B, Willbold D, Weiergräber OH
Conformational Polymorphism in Autophagy-Related Protein GATE-16
Biochemistry 54, 5469-5479 (2015)
- Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergräber OH
The mammalian autophagy initiator complex contains 2 HORMA domain proteins
Autophagy 11, 2300-2308 (2015)
http://dx.doi.org/10.1080/15548627.2015.1076605
- Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D
Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): Biophysical characterization and functional implications
J Biol Chem 288, 37204-37215 (2013)
- Weiergräber OH, Mohrlüder J, Willbold D
Atg8 family proteins –- autophagy and beyond
in: Autophagy - A double-edged sword - Cell survival or death? ISBN 978-953-51-1062-0, Editor: Yannick Bailly (2013)
open access
- Yerabham AS, Weiergräber OH, Bradshaw NJ, Korth C
Revisiting Disrupted-in-Schizophrenia 1 as a scaffold protein
Biol Chem 394, 1425-1437 (2013)
- Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergräber OH
Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain
Acta Cryst D68, 686-694 (2012)
http://dx.doi.org/10.1107/S0907444912008372
- Seebahn A, Dinkel H, Mohrlüder J, Hartmann R, Vogel N, Becker CM, Sticht H, Enz R
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors
FEBS Lett 585, 511-516 (2011)
- Ma P, Mohrlüder J, Schwarten M, Stoldt M, Singh SK, Hartmann R, Pacheco V, Willbold D
Preparation of a functional GABARAP-lipid conjugate in nanodiscs and its investigation by solution NMR spectroscopy
Chembiochem 11, 1967-1970 (2010)
- Pacheco V, Ma P, Thielmann Y, Hartmann R, Weiergräber OH, Mohrlüder J, Willbold D
Assessment of GABARAP self-association by its diffusion properties
J Biomol NMR 48, 49-58 (2010)
- Schwarten M, Stoldt M, Mohrlüder J, Willbold D
Solution structure of Atg8 reveals conformational polymorphism of the N-terminal domain
Biochem Biophys Res Commun 395, 426-431 (2010)
- Mohrlüder J, Schwarten M, Willbold D
Structure and potential function of gamma-aminobutyrate type A receptor-associated protein
FEBS J 276, 4989-5005 (2009)
- Schwarten M, Mohrlüder J, Ma P, Stoldt M, Thielmann Y, Stangler T, Hersch N, Hoffmann B, Merkel R, Willbold D
Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy
Autophagy 5, 690-698 (2009)
- Schwarten M, Stoldt M, Mohrlüder J, Willbold D
Sequence-specific 1H, 13C, and 15N resonance assignment of the autophagy-related protein Atg8
Biomol NMR Assign 3, 137-139 (2009)
- Thielmann Y, Weiergräber OH, Ma P, Schwarten M, Mohrlüder J, Willbold D
Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE-16
Proteins 77, 637-646 (2009)
- Thielmann Y, Weiergräber OH, Mohrlüder J, Willbold D
Structural characterization of GABARAP-ligand interactions
Mol Biosyst 5, 575-579 (2009)
- Thielmann Y, Weiergräber OH, Mohrlüder J, Willbold D
Structural framework of the GABARAP-calreticulin interface - implications for substrate binding to endoplasmic reticulum chaperones
FEBS J 276, 1140-1152 (2009)
- Thielmann Y, Mohrlüder J, Koenig BW, Stangler T, Hartmann R, Becker K, Höltje HD, Willbold D
An indole binding site is a major determinant of the ligand specificity of the GABA type A receptor-associated protein GABARAP
Chembiochem 9, 1767-1775 (2008)
- Weiergräber OH, Stangler T, Thielmann Y, Mohrlüder J, Wiesehan K, Willbold D
Ligand binding mode of GABAA receptor-associated protein
J Mol Biol 381, 1320-1331 (2008)
- Mohrlüder J, Hoffmann Y, Stangler T, Hänel K, Willbold D
Identification of clathrin heavy chain as a direct interaction partner for the gamma-aminobutyric acid type A receptor associated protein
Biochemistry 46, 14537-14543 (2007)
- Mohrlüder J, Stangler T, Wiesehan K, Hoffmann Y, Mataruga A, Willbold D
Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library
FEBS J 274, 5543-5555 (2007)
- Granzin J, Eckhoff A, Weiergräber OH
Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters
J Mol Biol 364, 799-809 (2006)
- Weiergräber OH, Eckhoff A, Granzin J
Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters
FEBS Lett 580, 251-255 (2006)
- Weiergräber OH, Senin II, Zernii EY, Churumova VA, Kovaleva NA, Nazipova AA, Permyakov SE, Permyakov EA, Philippov PP, Granzin J, Koch KW
Tuning of a neuronal calcium sensor
J Biol Chem 281, 37594-37602 (2006)
- Eckhoff A, Granzin J, Kamphausen T, Büldt G, Schulz B, Weiergräber OH
Crystallization and preliminary X-ray analysis of immunophilin-like FKBP42 from Arabidopsis thaliana
Acta Crystallogr F 61, 363-365 (2005)
- Komolov KE, Zinchenko DV, Churumova VA, Vaganova SA, Weiergräber OH, Senin II, Philippov PP, Koch KW
One of the Ca2+ binding sites of recoverin exclusively controls interaction with rhodopsin kinase
Biol Chem 386, 285-289 (2005)
- Senin II, Vaganova SA, Weiergräber OH, Ergorov NS, Philippov PP, Koch KW
Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant
J Mol Biol 330, 409-418 (2003)
- Weiergräber OH, Senin II, Philippov PP, Granzin J, Koch KW
Impact of N-terminal myristoylation on the Ca2+-dependent conformational transition in recoverin
J Biol Chem 278, 22972-22979 (2003)
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