Willuweit A, Humpert S, Schöneck M, Endepols H, Burda N, Gremer L, Gering I, Kutzsche J, Shah NJ, Langen KJ, Neumaier B, Willbold D, Drzezga A. Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging Eur J Pharm Sci 184:106421, (2023) https://doi.org/10.1016/j.ejps.2023.106421 https://pubmed.ncbi.nlm.nih.gov/36889654/
Maity D, Oh Y, Gremer L, Hoyer W, Magzoub M, Hamilton AD Cucurbit[7]uril inhibits islet amyloid polypeptide aggregation by targeting N terminus hot segments and attenuates cytotoxicity Chemistry , e202200456 (2022) https://doi.org/10.1002/chem.202200456
Törner R, Kupreichyk T, Gremer L, Debled EC, Fenel D, Schemmert S, Gans P, Willbold D, Schoehn G, Hoyer W, Boisbouvier J Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin Nat Commun 13, 2363 (2022) https://doi.org/10.1038/s41467-022-30042-y
Bocharov, E. V., L. Gremer, A. S. Urban, I. S. Okhrimenko, P. E. Volynsky, K. D. Nadezhdin, O. V. Bocharova, D. A. Kornilov, Y. A. Zagryadskaya, A. V. Kamynina, P. K. Kuzmichev, J. Kutzsche, N. Bolakhrif, A. Müller-Schiffmann, N. A. Dencher, A. S. Arseniev, R. G. Efremov, V. I. Gordeliy and D. Willbold All-d-Enantiomeric Peptide D3 Designed for Alzheimer’s Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors. Journal of Medicinal Chemistry , (2021) https://doi.org/10.1021/acs.jmedchem.1c00632
König AS, Rösener NS, Gremer L, Tusche M, Flender D, Reinartz E, Hoyer W, Neudecker P, Willbold D, Heise H Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy J Biol Chem 296, 100499 (2021) https://doi.org/10.1016/j.jbc.2021.100499
Maity D, Kumar S, AlHussein R, Gremer L, Howarth M, Karpauskaite L, Hoyer W, Magzoubd M, Hamilton AD Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to antiamyloid agents RSC Chem. Biol. 1, 225-232 (2020) https://doi.org/10.1039/D0CB00086H
Rösener NS, Gremer L, Wördehoff MM, Kupreichyk T, Etzkorn M, Neudecker P, Hoyer W Clustering of human prion protein and α-synuclein oligomers requires the prion protein Nterminus Commun. Biol. 3, 365 (2020) https://doi.org/10.1038/s42003-020-1085-z
Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication J Biol Chem 294, 7388-7402 (2019) https://doi.org/10.1074/jbc.RA119.007656
Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M Origin of metastable oligomers and their effects on amyloid fibril self-assembly Chem. Sci. 9, 5937-5948 (2018) https://doi.org/10.1039/c8sc01479e
Rösener NS, Gremer L, Reinartz E, König A, Brener O, Heise H, Hoyer W, Neudecker P, Willbold D A d-enantiomeric peptide interferes with heteroassociation of amyloid-β oligomers and prion protein J. Biol. Chem. 293, 15748-15764 (2018) https://doi.org/10.1074/jbc.RA118.003116
Dammers C, Reiss K, Gremer L, Lecher J, Ziehm T, Stoldt M, Schwarten M, Willbold D. Pyroglutamate-modified amyloid-β(3-42) shows α-helical intermediates before amyloid formation. Biophys. J. 112, 1621-1633 (2017)
Elfgen A, Santiago-Schübel B, Gremer L, Kutzsche J, Willbold, D Surprisingly high stability of the Aβ oligomer eliminating all-D-enantiomeric peptide D3 in media simulating the route of orally administered drugs European Journal of Pharmaceutical Sciences 107, 203-207 (2017) https://doi.org/10.1016/j.ejps.2017.07.015 https://www.ncbi.nlm.nih.gov/pubmed/28711713
Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D Optimization of D-peptides for Aβ monomer binding specificity enhances their potential to eliminate toxic Aβ oligomers ACS Chem Neurosci 8, 1889-1900 (2017)
van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D. The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology. Sci Rep. 7, 16275 (2017) https://doi.org/10.1038/s41598-017-16565-1 https://www.nature.com/articles/s41598-017-16565-1
Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg LU, Lothmann K,Rizzi F, Schaller M, Gohlke H, Willbold D, Grenegard M, Elvers M. Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release Sci Signal 9(429), ra52 (2016) http://10.1126/scisignal.aaf6240 http://stke.sciencemag.org/content/9/429/ra52.long
Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D. Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. PLoS One 11(4), (2016) http://dx.doi.org/10.1371/journal.pone.0153035 Erratum in: PLoS One. 2016;11(7):e0158960. http://dx.doi.org/10.1371/journal.pone.0158960
Weirich F, Gremer L, Mirecka EA, Schiefer S, Hoyer W, Heise H Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core PLOS One 11, e0161243 (2016) http://dx.doi.org/10.1371/journal.pone.0161243
Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D. Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species. ACS Chem Neurosci. 7 (8), 1088–1096 (2016) http://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00047
Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen K-J, Demuth H-U, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers. Sci Rep 5, 13222 (2015) http://dx.doi.org/10.1038/srep13222
Dammers C, Gremer L, Neudecker P, Demuth HU, Schwarten M, Willbold D Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy PLoS One 10, e0139710 (2015)
Dammers C, Gremer L, Reiß K, Klein AN, Neudecker P, Hartmann R, Sun N, Demuth HU, Schwarten M, Willbold D Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol
PLoS One 10, e0143647 (2015)
Jiang N, Leithold LH, Post J, Ziehm T, Mauler J, Gremer L, Cremer M, Schartmann E, Shah NJ, Kutzsche J, Langen KJ, Breitkreutz J, Willbold D, Willuweit A Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease PLoS One 10, e0128553 (2015)
Gauhar A, Shaykhalishahi H, Gremer L, Mirecka EA, Hoyer W Impact of subunit linkages in an engineered homodimeric binding protein to alpha-synuclein Protein Eng. Des. Sel. 27, 473-479 (2014) http://dx.doi.org/10.1093/protein/gzu047
Mirecka EA, Gremer L, Schiefer S, Oesterhelt F, Stoldt M, Willbold D, Hoyer W Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide J. Biotechnol. 191, 221-227 (2014) http://dx.doi.org/10.1016/j.jbiotec.2014.06.006
Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR Rho-kinase: regulation, (dys)function, and inhibition Biol Chem. 394, 1399-1410 (2013) full text
Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division Biol Chem 394, 1411-1423 (2013) full text
Sun N, Hartmann R, Lecher J, Stoldt M, Funke SA, Gremer L, Ludwig H-H, Demuth H-U, Kleinschmidt M, Willbold D Structural analysis of the pyroglutamate modified isoform of the Alzheimer's disease related beta-amyloid using NMR spectroscopy. J. Pept. Science 18, 691-695 (2012)