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Publikationen

  • Agerschou ED, Schützmann MP, Reppert N, Wördehoff MM, Shaykhalishahi H, Buell AK, Hoyer W 
    β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation 
    Biophys. Chem. , (2020) 
    https://doi.org/10.1016/j.bpc.2020.106519  
  • Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenburger B, Hoyer W, Buell AK 
    An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils 
    eLife 8, e46112 (2019) 
    https://doi.org/10.7554/eLife.46112  
  • Falke M, Victor J, Wördehoff MM, Peduzzo A, Zhang T, Schröder GF, Buell AK, Hoyer W, Etzkorn M 
    α-Synuclein-derived lipoparticles in the study of α-synuclein amyloid fibril formation 
    Chem Phys Lipids 220, 57-65 (2019) 
    https://doi.org/10.1016/j.chemphyslip.2019.02.009  
  • Röder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schröder GF 
    Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy 
    Nat. Commun. 10, 3754 (2019) 
    https://doi.org/10.1038/s41467-019-11320-8  
  • Viennet T, Wördehoff MW, Uluca B, Poojari C, Shaykhalishahi H, Willbold D, Strodel B, Heise H, Buell AK, Hoyer W, Etzkorn M: 
    Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation 
    Commun. Biol. 1, 44 (2018) 
    https://doi.org/10.1038/s42003-018-0049-z  
  • Dammers C, Schwarten M, Buell AK, Willbold D 
    Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways 
    Chem. Sci. 8, 4996-5004 (2017) 
    http://pubs.rsc.org/en/content/articlehtml/2017/sc/c6sc04797a  
  • Wördehoff M, Shaykhalishahi H, Groß L, Gremer L, Stoldt M, Buell AK, Willbold D, Hoyer W 
    Opposed effects of dityrosine formation in soluble and aggregated α-synuclein on fibril growth 
    J. Mol. Biol. 429, 3018-3030 (2017) 
    https://doi.org/10.1016/j.jmb.2017.09.005  
    http://www.sciencedirect.com/science/article/pii/S0022283617304278  
  • Alexander K. Buell 
    The nucleation of protein aggregates – from crystals to fibrils 
    International Review of Cell and Molecular Biology , (2016) 
    http://dx.doi.org/10.1016/bs.ircmb.2016.08.014  
  • Anđela Šarić, Alexander K. Buell, Georg Meisl, Thomas C. T. Michaels, Sara Linse, Tuomas P. J. Knowles and Daan Frenkel 
    Physical determinants for the self-replication of protein fibrils 
    Nature Physics 12, 874-880 (2016) 
    http://www.nature.com/nphys/journal/v12/n9/full/nphys3828.html  
  • Céline Galvagnion, James Brown, Myriam M. Ouberai, Patrick Flagmeier, Michele Vendruscolo, Alexander K. Buell, Emma Sparr and Christopher M. Dobson 
    The chemical properties of lipids strongly affect the rate of the nucleation step in the membrane-induced aggregation of α-synuclein 
    PNAS 113(26), 7065-7070 (2016) 
    http://www.pnas.org/content/113/26/7065  
  • Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Christopher M. Dobson, Clemens F. Kaminski, Gabriele S. Kaminski Schierle 
    Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons 
    PNAS 113(14), 3815-3819 (2016) 
    http://www.pnas.org/content/113/14/3815  
  • Giulio Costantini, Zoe Budrikis, Alessandro Taloni, Alexander K. Buell, Stefano Zapperi and Caterina A.M. La Porta 
    Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease 
    Phys Rev Appl 6, 034012 (2016) 
    http://journals.aps.org/prapplied/abstract/10.1103/PhysRevApplied.6.034012  
  • James Brown, Alexander K. Buell, Thomas C.T. Michaels, Georg Meisl, Jackie Carozza, Patrick Flagmeier, Michele Vendruscolo, Tuomas P.J. Knowles, Christopher M. Dobson, Céline Galvagnion 
    β-synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding 
    Scientific Reports 6, 36010 (2016) 
    http://www.nature.com/articles/srep36010  
  • Manuel Wolff, Judith J. Mittag, Therese W. Herling, Erwin De Genst, Christopher M. Dobson, Tuomas P.J. Knowles, Dieter Braun and Alexander K. Buell 
    Quantitative thermophoretic study of disease-related protein aggregates 
    Scientific Reports 6, 22829 (2016) 
    http://www.nature.com/articles/srep22829  
  • Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas PJ Knowles, Christopher M. Dobson, Alexander K. Buell and Céline Galvagnion 
    Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein amyloid formation 
    PNAS 113(37), 10328-10333 (2016) 
    http://www.pnas.org/content/113/37/10328  
  • Thomas O. Mason, Thomas C.T. Michaels, Aviad Levin, Ehud Gazit, Christopher M. Dobson, Alexander K. Buell and Tuomas P. J. Knowles 
    Synthesis of non-equilibrium supra-molecular peptide polymers on a microfluidic platform 
    JACS 138(30), 9589-9596 (2016) 
    http://pubs.acs.org/doi/abs/10.1021/jacs.6b04136  
  • Yingbo Zhang, Alexander K. Buell, Thomas Müller, Erwin De Genst, Justin Benesch, Christopher M. Dobson and Tuomas P. J. Knowles 
    Protein aggregate-ligand binding assays based on microfluidic diffusional separation 
    ChemBioChem 17(20), 1920-1924 (2016) 
    http://onlinelibrary.wiley.com/doi/10.1002/cbic.201600384/abstract  
  • Céline Galvagnion and Alexander K. Buell 
    Fundamental mechanisms of amyloid fibril formation by alpha-synuclein in Parkinson's disease: quantitative modelling 
    Med Sci (Paris) 31, 597-600 (2015) 
    http://www.medecinesciences.org/en/articles/medsci/abs/2015/07/medsci2015316-7p597/medsci2015316-7p597.html  
  • Céline Huynen, Nicolas Willet, Alexander K. Buell, Anne-Sophie Duwez, Christine Jerôme and Mireille Dumoulin 
    Influence of the protein context on the polyQ length dependent elongation rate of amyloid fibrils 
    Biochim. Biophys. Acta – Proteins & Proteomics 1854(3), 239-248 (2015) 
    http://www.sciencedirect.com/science/article/pii/S1570963914003185  
  • Galvagnion C, Buell AK, Meisl G, Michaels TCT, Vendruscolo M, Knowles TPJ and Dobson CM 
    Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. 
    Nat. Chem. Biol. 11, 229-234 (2015) 
    Link to full text  
  • Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Dobson CM, Weitz DA and Knowles TPJ 
    Controlled structuring of protein-only amyloid nanofibril networks into 3D microgel particles 
    ACS Nano 9(1), 43-51 (2015) 
    Link to full text  
  • Thomas C.T. Michaels, Pernille Yde, Julian C.W. Willis, Mogens H. Jensen, Daniel E. Otzen, Christopher M. Dobson, Alexander K. Buell and Tuomas P.J. Knowles 
    The length distribution of frangible biofilaments 
    J Chem Phys 143, 164901 (2015) 
    http://aip.scitation.org/doi/abs/10.1063/1.4933230?journalCode=jcp  
  • Alexander K. Buell, Céline Galvagnion, Ricardo Gaspar, Emma Sparr, Michele Vendruscolo, Tuomas P.J. Knowles, Sara Linse and Christopher M. Dobson 
    Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation 
    PNAS 111(21), 7671-7676 (2014) 
    http://www.pnas.org/content/111/21/7671  
  • Alexander K. Buell, Christopher M. Dobson and Tuomas P.J. Knowles 
    The physical chemistry of the amyloid phenomenon - thermodynamics and kinetics of filamentous protein aggregation 
    Essays Biochem 56(1), 11-39 (2014) 
    http://essays.biochemistry.org/content/56/11  
  • Aviad Levin, Thomas Mason, Lihi Adler-Abramovich, Alexander K. Buell, Georg Meisl, Céline Galvagnion, Yaron Bram, Samuel A. Stratford, Christopher M. Dobson, Tuomas P.J. Knowles and Ehud Gazit 
    Ostwald's rule of stages governs structural transitions and morphological control of a dipeptide supramolecular polymer 
    Nature Communications 5, 5219 (2014) 
    http://www.nature.com/articles/ncomms6219  
  • Dorothea Pinotsi, Alexander K. Buell, Celine Galvagnion, Christopher M. Dobson, Gabriele S. Kaminski Schierle and Clemens F. Kaminski  
    Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy 
    Nano Letters 14(1), 339-345 (2014) 
    http://pubs.acs.org/doi/abs/10.1021/nl4041093  
  • Nikolai Lorenzen, Søren Bang Nielsen, Alexander K. Buell, Jørn Døvling Kaspersen, Paolo Arosio, Brian Stougaard Vad, Gunna Christiansen, Zuzana Valnickova-Hansen, Maria Andreasen, Wojciech Paslawski, Jan J. Enghild, Christopher M. Dobson, Tuomas P. J. Knowles, Jan Skov Pedersen and Daniel Erik Otzen 
    The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation 
    JACS 136, 3859-3868 (2014) 
    http://pubs.acs.org/doi/abs/10.1021/ja411577t  
  • Samuel I. A. Cohen, Luke Rajah, Chang-Ho Yoon, Alexander K. Buell, Duncan A. White, Ralf A. Sperling, Michele Vendruscolo, Eugene M. Terentjev, Christopher M. Dobson, David A. Weitz and Tuomas P. J. Knowles 
    Spatial propagation of protein polymerisation 
    Physical Review Letters 12, 098101 (2014) 
    http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.112.098101  
  • Thomas C.T. Michaels, Alexander K. Buell, Eugene M. Terentjev and Tuomas P.J. Knowles 
    Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems 
    J Phys Chem Lett 5, 695-699 (2014) 
    http://pubs.acs.org/doi/abs/10.1021/jz4024833  
  • Thomas O. Mason, Dimitri Y. Chirgadze, Aviad Levin, Lihi Adler-Abramovich, Ehud Gazit, Tuomas P.J. Knowles and Alexander K. Buell 
    Expanding the solvent chemical space for self-assembly of dipeptide nanostructures 
    ACS Nano 8, 1243-1253 (2014) 
    http://pubs.acs.org/doi/abs/10.1021/nn404237f  
  • Alexander K. Buell, Peter Hung, Xavier Salvatella, Mark E. Welland, Christopher M. Dobson and Tuomas P. J. Knowles 
    Electrostatic effects in filamentous protein aggregation 
    Biophysical Journal 104, 1116-1126 (2013) 
    http://www.cell.com/biophysj/abstract/S0006-3495(13)00136-7  
  • Andrea Pica, Antonello Merlino, Alexander K. Buell, Tuomas P.J. Knowles, Elio Pizzod, Giuseppe D'Alessio, Filomena Sica and Lelio Mazzarella 
    3D domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase 
    Acta Cryst. D 69, 2116-2123 (2013) 
    http://scripts.iucr.org/cgi-bin/paper?S0907444913020507  
  • Dorothea Pinotsi, Alexander K. Buell, Christopher M. Dobson, Gabriele S. Kaminski Schierle and Clemens F. Kaminski 
    A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence 
    ChemBioChem 14, 846-850 (2013) 
    http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300103/abstract  
  • Li-Qiong Xu, Si Wu, Alexander K. Buell, Samuel I. A. Cohen, Li-Jun Chen, Wan-Hui Hu, Sarah A. Cusack, Laura S. Itzhaki, Hong Zhang, Tuomas P. J. Knowles, Christopher M. Dobson, Mark E. Welland, Gary W. Jones and Sarah Perrett 
    Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2 
    Philos Trans R Soc Lond B Biol Sci 368, 20110410 (2013) 
    http://rstb.royalsocietypublishing.org/content/368/1617/20110410.long  
  • Tim Guilliams, Farah El-Turk, Alexander K. Buell, Elizabeth O'Day, Francesco Aprile, Elin K. Esbjörner, Michele Vendruscolo, Nunilo Cremades, Els Pardon, Lode Wyns, Mark E. Welland, Jan Steyaert, John Christodoulou, Christopher M. Dobson and Erwin De Genst 
    Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages 
    J Mol Biol 425, 2397-2411 (2013) 
    http://www.sciencedirect.com/science/article/pii/S0022283613001897  
  • Alexander K. Buell, Anne Dhulesia, Duncan A. White, Tuomas P.J. Knowles, Christopher M. Dobson, Mark E. Welland 

    Angewandte Chemie Int Ed 51, 5247-5251 (2012) 
    http://onlinelibrary.wiley.com/doi/10.1002/anie.201108040/abstract  
  • Alexander K. Buell, Christopher M. Dobson, Mark E. Welland 
    Measuring the kinetics of amyloid fibril elongation using Quartz Crystal Microbalances (QCM) 
    Amyloid proteins - Methods and Protocols 849, 101-119 (2012) 
    http://link.springer.com/protocol/10.1007%2F978-1-61779-551-0_8  
  • Cintia Roodveldt, August Andersson, Erwin J. De Genst, Adahir Labrador-Garrido, Alexander K. Buell, Christopher M. Dobson, Gian Gaetano Tartaglia and Michele Vendruscolo 
    A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein 
    Biochemistry 51, 8771-8778 (2012) 
    http://pubs.acs.org/doi/abs/10.1021/bi300558q  
  • Alexander K. Buell, Anne Dhulesia (joint first authors), Maria F. Mossuto, Nunilo Cremades, Janet R. Kumita, Mireille Dumoulin, Mark E. Welland, Tuomas P. J. Knowles, Xavier Salvatella, Christopher M. Dobson 
    Population of non-native states of lysozyme mutants drives amyloid fibril formation 
    JACS 133, 7737-7743 (2011) 
    http://pubs.acs.org/doi/abs/10.1021/ja109620d  
  • Alexander K. Buell, Elin K. Esbjörner, Patrick J. Riss, Duncan A. White, Franklin I. Aigbirhio, Gergely Toth, Mark E. Welland, Christopher M. Dobson and Tuomas P.J. Knowles 
    Probing small molecule binding to amyloid fibrils 
    Phys Chem Chem Phys 13, 20044-20052 (2011) 
    https://www.ncbi.nlm.nih.gov/pubmed/22006124  
  • Sarah L. Shammas, Christopher A. Waudby, Shuyu Wang, Alexander K. Buell, Tuomas P.J. Knowles, Heath Ecroyd, Mark E. Welland, John A. Carver, Christopher M. Dobson and Sarah Meehan 
    Binding of the Molecular Chaperone alpha B-Crystallin to Abeta Amyloid Fibrils Inhibits Fibril Elongation 
    Biophysical Journal 101, 1681-1689 (2011) 
    https://www.ncbi.nlm.nih.gov/pubmed/21961594  
  • Yi-Qian Wang, Alexander K. Buell, Xin-Yu Wang, Mark E. Welland, Christopher M. Dobson, Tuomas P.J Knowles, Sarah Perrett 
    Relationship Between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly 
    J Biol Chem 286, 12101-12107 (2011) 
    http://www.jbc.org/content/286/14/12101.long  
  • Alexander K. Buell, Christopher M. Dobson, Tuomas P.J. Knowles and Mark E. Welland 
    Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors 
    Biophysical Journal 99(10), 3492-3497 (2010) 
    http://www.cell.com/biophysj/references/S0006-3495(10)01108-2  
  • Alexander K. Buell, Duncan A. White, Christoph Meier, Mark E. Welland, Tuomas P.J. Knowles and Christopher M. Dobson 
    Surface attachment of protein fibrils via covalent modication strategies 
    J Phys Chem B 114, 10925-10938 (2010) 
    http://pubs.acs.org/doi/abs/10.1021/jp101579n  
  • Alexander K. Buell, Jamie R. Blundell, Christopher M. Dobson, Mark E. Welland, Eugene M. Terentjev and Tuomas P. J. Knowles 
    Frequency factors in a landscape model of filamentous protein aggregation 
    Physical Review Letters 104, 228101 (2010) 
    http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.228101  
  • Duncan A. White, Alexander K. Buell, Tuomas P.J. Knowles, Mark E. Welland and Christopher M. Dobson 
    Protein aggregation in crowded environments 
    JACS 132(14), 5170-5175 (2010) 
    http://pubs.acs.org/doi/abs/10.1021/ja909997e  
  • Tuomas P. J. Knowles, Tomas W. Oppenheim, Alexander K. Buell, Dimitri Y. Chirgadze and Mark E. Welland 
    Nanostructured films from hierarchical self-assembly of amyloidogenic proteins 
    Nature Nanotechnology 5, 204-207 (2010) 
    http://www.nature.com/nnano/journal/v5/n3/abs/nnano.2010.26.html  
  • Alexander K. Buell, Gian Gaetano Tartaglia, Neil R. Birkett, Christopher A. Waudby, Michele Vendruscolo, Xavier Salvatella, Mark E. Welland, Christopher M. Dobson and Tuomas P.J. Knowles 
    Position dependent electrostatic protection against protein aggregation 
    ChemBioChem 10(8), 1309-1312 (2009) 
    http://onlinelibrary.wiley.com/doi/10.1002/cbic.200900144/abstract  
  • Duncan A. White, Alexander K. Buell, Christopher M. Dobson, Mark E. Welland and Tuomas P.J. Knowles 
    Biosensor-based label-free assays of amyloid growth 
    FEBS Lett 583(16), 2587-2592 (2009) 
    http://www.sciencedirect.com/science/article/pii/S0014579309004517  
  • W. Scott Hopkins, Hans-Peter Loock, Brid Cronin, Michael G. D. Nix, Adam L. Devine, Richard N. Dixon, Michael N. R. Ashfold, Hong-Ming Yin, Steven J. Rowling, Alexander Büll and Scott H. Kable 
    Quantitative (v, N, Ka ) product state distributions near the triplet threshold for the reaction H2CO → H + HCO measured by Rydberg tagging and laser-induced fluorescence 
    J Phys Chem A 112(39), 9283-9289 (2008) 
    http://pubs.acs.org/doi/abs/10.1021/jp8021826?src=recsys&journalCode=jpcafh  
  • Hong-Ming Yin, Steven J. Rowling, Alexander Büll and Scott H. Kable 
    Photodissociation dynamics of the reaction H2CO → H+HCO via the singlet (S0) and triplet (T1) surfaces 
    J Chem Phys 127(6), 064302 (2007) 
    http://aip.scitation.org/doi/abs/10.1063/1.2752161?journalCode=jcp  
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