Welcome to Institut für Physikalische Biologie

The function of each cell and each organism decisively depends on the dynamic interactions between biological macromolecules and on their correct three-dimensional structure. Faulty interaction and incorrectly folded structures eventually lead to diseases and ageing. Our aim is to understand these interactions and to determine the three-dimensional structure of the protein complexes involved in decisive cellular processes - if possible, in atomic resolution. Beyond that, we develop novel methods for the early diagnosis and treatment of neurodegenerative diseases, with a strong focus on Alzheimer's dementia. undefined[more]

Prof. Dr. Dieter Willbold is the director of the institute. His Department focusses on Modelling Systems, Virus-Host-Interaction and Neurofunction/Neurodegeneration. undefined[more] The Department of Prof. Dr. Henrike Heise is developing new methods in the field of solid state NMR-Spektroscopy.

A close cooperation exists with the undefinedInstitute of Complex Systems (ICS-6: Structural Biochemistry) at Forschungszentrum Jülich, which is also headed by Prof. Dr. Willbold. Together, the two institutes run the undefinedBiomolecular NMR-Center in Jülich.

A close cooperation exists with the undefinedInstitute of Complex Systems (ICS-6: Structural Biochemistry) at Forschungszentrum Jülich, which is also headed by Prof. Dr. Willbold.

Together, the two institutes run the Biomolecular NMR-Center in Jülich.

17.04.18 First human volunteer recruited: Start of Phase I-study for Alzheimer's therapy

The Phase I clinical study, in which the new Alzheimer's drug candidate PRI-002 is being tested for the first time in humans, has now officially started in Vienna. On Monday, PRI-002 was administered to the first healthy volunteer. The study will evaluate the safety and tolerability of the oral dosage form of PRI-002 in healthy volunteers. Prof. Dieter Willbold, developer of PRI-002 and director of the Institut für Physikalische Biologie, was present in Vienna while the Phase I study started.

18.03.18 Lessons from yeast may help tackle dementia

Together with Japanese colleagues, biophysicists at Heinrich Heine University Düsseldorf (HHU) and Jülich Research Centre have examined the folding of specific proteins in yeast fungi. They discovered similar mechanisms to those found in prions, i.e. proteins that are misfolded and can trigger neurodegenerative diseases. From the prions in yeast, the researchers were able to acquire new insights into the misfolding of these harmful proteins. Their results have been published in the scientific journal Proceedings of the National Academy of Sciences (PNAS).

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