Welcome

Dieter Willbold

Deputy Speaker of BMFZ, Institute of Physical Biology, Heinrich Heine University Düsseldorf, Germany

Andreas Andreas Reichert 

Speaker of BMFZ, Institute of Biochemistry and Molecular Biology I, Heinrich Heine University Düsseldorf, Germany

Welcome addresses

Anja Steinbeck

President of Heinrich Heine University Düsseldorf, Germany

Linda Thienpont

Deputy managing director, Alzheimer Forschung Initiative e.V., Düsseldorf, Germany

SESSION I: Amyloids

Chair: Erdem Gültekin Tamgüney, Heinrich Heine University

Prions: From violent refusal to general concept of neurodegenerative diseases.

Detlev Riesner

Institute of Physical Biology, Heinrich Heine University Düsseldorf, Germany

How do we remember Alzheimer's disease?

Thomas van Groen

Dept. Pediatrics-Neonatology, University of Alabama at Birmingham, USA

RNA-binding protein phase transitions and their relevance for amyloid formation

Dorothee Dormann

Institute of Molecular Physiology, Johannes Gutenberg University, Mainz, Germany

Nuclear TDP-43 dysfunction releases endogenous retrotransposons from suppression in neurodegenerative disease

Roger Sher

Department of Neurobiology and Behavior, Stony Brook University, New York, USA

Efficacy and mechanisms of targeting intracellular protein aggregates 

Rakez Kayed

Mitchell Center for Neurodegenerative Disorders, John Sealy Chair for Parkinson's Research, Dept. of Neurology, UTMB Health - University of Texas, USA

Talk by early career scientist

Disassembly of a-synuclein aggregates by the all-D-peptide PRI-101: preclinical efficacy in vitro and in vivo 

Marc Sevenich

Priavoid GmbH, Düsseldorf, Germany

SESSION II: Genetic risk factors

Chair: Sascha Weggen, Heinrich Heine University

The impact of rare genetic variants on Alzheimer’s disease

Lara De Deyn

Center for Molecular Neurology, University of Antwerp, Belgium

Talk by early career scientist

Whole-brain mapping of Parkinson’s disease pathologies in mices

Ruiqing Ni

University of Zürich, Switzerland

The molecular basis of ApoE4 risk in alzheimer's disease

Joachim Herz

UTSouthwestern Medical Center, Dallas, Texas, USA

Talk by early career scientist

Long-term air Pollution, Cognitive Decline, and Neurodegeneration

Katherine Ogurtsova

Institute of Occupational, Social and Environmental Medicine, Heinrich Heine University Düsseldorf, Germany

PUBLIC SCIENCE LECTURE

jointly organized with Alzheimer Forschung Initiative e.V. (AFI)

Chair: Okka Gundel, German journalist, television presenter and author

Neue Hoffnung bei Alzheimer? Praktische Antworten zu den neuen Medikamenten

Sabine Kuckert

Memory Zentrum Neuss, Germany

SESSION III: From lab to market: Industry insights: latest R&D developments

Chair: Wolfgang Hoyer, Heinrich Heine University

The nose - a window to the brain

Mareike Albert

Founder & CSO of Noselab

Talk by early career scientist

A new strategy to target pGlu3-Ab

Steffen Roßner

Paul Flechsig Institute - Centre of Neuropathology and Brain Research, Faculty of Medicine, University of Leipzig, Germany

Targeting pathological alpha-synuclein aggregates with small molecules

Armin Giese

MODAG Neuroscience Solutions

SESSION IV: Basic science

Chair: Carsten Korth, Heinrich Heine University Düsseldorf

On the structural polymorphisms of a-synuclein in vitro and in cells

Roland Riek

Dept. of Chemistry and Applied Biosciences, Deputy head of Institute of Molecular Physical Science, ETH Zürich, Switzerland

Inflection Points in Alzheimer’s Disease: From Molecular Triggers to Cellular Dysregulation

Bart De Strooper

UCL Queen Square Institute of Neurology, University College London, England

Flash Talks Part 1

9 poster presenters, one single slide, 90 sec time per talk.

Novel functions of oligodendrocytes in energy metabolism and Alzheimer’s disease

Klaus-Armin Nave

Dept. of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany

Flash Talks Part 2

10 poster presenters, one single slide, 90 sec time per talk.

Funding opportunities: Alzheimer Forschung Initiative e.V. (AFI)

Anne Pfitzer-Bilsing

Director of Scientific Affairs, Alzheimer Forschung Initiative e.V., Düsseldorf, Germany

SESSION V: Noble lecture

Chair: Dieter Willbold, Heinrich Heine University Düsseldorf

The Molecular Biology and Pathogenesis of Prion Diseases

Stan Prusiner

Nobel Prize in Physiology or Medicine for his discovery of Prions - a new biological principle of infection

Director, Institute for Neurodegenerative Diseases

University of California San Francisco, USA

SESSION VI: Clinical insights and sex differences in clinical trial outcome

Chair: Alfons Schnitzler, Heinrich Heine University Düsseldorf

Biomarker-based neurobiological staging and treatment of Alzheimer´s disease

Oliver Peters

Department of Psychiatry and Neuroscience CBF, Charité - Universitätsmedizin Berlin und Priavoid, Germany

Talk by early career scientist

Let’s Talk About Sex Differences in Brain Aging

Elena Doering

Clinic and Polyclinic for Nuclear Medicine, University Hospital Cologne, Germany

Genetics and Sex in Alzheimer's Disease and Related Dementias

Celine Bellenguez

Institute Pasteur de Lille, University Lille, France

Session VII: AWARDS and Closing

Chair: Inga Kadish, University of Alabama at Birmingham, USA

I. Ulrich Hadding Award, 

II. Egon Nettersheim Award

Guido Reifenberger

Vice Dean of the Medical Faculty, Heinrich Heine University Düsseldorf, Germany

Poster prizes

sponsored by Alzheimer Forschung Initiative e.V.

Inga Kadish^a and Anne Pfitzer-Bilsing^b

^aHeersink School of Medicine, Dept. Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, USA

^bDirector of Scientific Affairs, Alzheimer Forschung Initiative e.V., Düsseldorf, Germany

Closing remarks

Inga Kadish^a and Thomas van Groen^b

^aHeersink School of Medicine, Dept. Cell, Developmental and Integrative Biology,

University of Alabama at Birmingham, USA

^bDept. Pediatrics-Neonatology, University of Alabama at Birmingham, USA