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Publikationen in 2019

  • Abdollahzadeh I, Hendriks J, Sanwald JL, Simons IM, Hoffmann S, Weiergräber OH, Willbold D, Gensch T 
    Autophagy-Related Proteins GABARAP and LC3B Label Structures of Similar Size but Different Shape in Super-Resolution Imaging 
    Molecules 24, E1833 (2019) 
  • Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenburger B, Hoyer W, Buell AK 
    An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils 
    eLife 8, e46112 (2019) 
  • Alvarez CE, Bovdilova A, Höppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG. 
    Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses. 
    Nat Plants 5(7), 755-765 (2019) 
  • Bleffert F, Granzin J, Gohlke H, Batra-Safferling R, Jaeger KE, Kovacic F 
    Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization. 
    Acta Crystallography F75, 270-277 (2019) 
  • Bovdilova A, Alexandre BM, Höppner A, Luís IM, Alvarez CE, Bickel D, Gohlke H, Decker C, Nagel-Steger L, Alseekh S, Fernie AR, Drincovich MF, Abreu IA, Maurino VG. 
    Posttranslational Modification of the NADP-Malic Enzyme Involved in C4 Photosynthesis Modulates the Enzymatic Activity during the Day. 
    Plant Cell 31(10), 2525-2539 (2019) 
  • Dieter Willbold and Janine Kutzsche 
    Do We Need Anti-Prion Compounds to Treat Alzheimer’s Disease? 
    Molecules 24, 2237 (2019) 
  • Elfgen A, Hupert M, Bochinsky K, Tusche M, González de San Román Martin E, Gering I, Sacchi S, Pollegioni L, Huesgen PF, Hartmann R, Santiago-Schübel B, Kutzsche J, Willbold D. 
    Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers 
    Sci Rep 9(1), 5715 (2019) 
  • Falke M, Victor J, Wördehoff MM, Peduzzo A, Zhang T, Schröder GF, Buell AK, Hoyer W, Etzkorn M 
    α-Synuclein-derived lipoparticles in the study of α-synuclein amyloid fibril formation 
    Chem Phys Lipids 220, 57-65 (2019) 
  • Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D 
    Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication 
    J Biol Chem 294, 7388-7402 (2019) 
  • Krichel C, Möckel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergräber OH, Willbold D, Neudecker P 
    Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site 
    Sci Rep 9, 14167 (2019) 
  • Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-RosenkranzP, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, PfefferK, Beer-Hammer S, Willbold D, Koenig BW 
    Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association 
    Scientific Reports 9, 54 (2019) 
  • Lohmann S, Bernis ME, Babila JT, Ziemski A, Grigoletto J, Tamgüney G 
    Oral and intravenous transmission of α-synuclein prions to mice 
    Acta Neuropathol 138, 515-533 (2019) 
  • Lorenz C, Ince S, Zhang T, Cousin A, Batra-Safferling R, Nagel-Steger L, Herrmann C, Stadler AM. 
    Farnesylation of human guanylate-binding protein 1 as safety mechanism preventing structural rearrangements and uninduced dimerization. 
    FEBS J Epub ahead of print, Epub ahead of print (2019) 
  • Nerius M, Doblhammer G, Tamgüney G 
    GI infections are associated with an increased risk of Parkinson’s disease 
    Gut 66, 1-2 (2019) 
  • Perez C, Miti T, Hasecke F, Meisl G, Hoyer W, Muschol M, Ullah G 
    Mechanism of fibril and soluble oligomer formation in amyloid β and hen egg white lysozyme proteins 
    J. Phys. Chem. B 123, 5678-5689 (2019) 
  • Porta N, Zaschke-Kriesche J, Frieg J, Gopalswamy M, Zivkovic A, Etzkorn M, Stark H, Smits S, Gohlke H 
    Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae  
    Bioorg Med Chem 27, 115079 (2019) 
  • Röder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schröder GF 
    Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy 
    Nat. Commun. 10, 3754 (2019) 
  • Schemmert S, Schartmann E, Honold D, Zafiu C, Ziehm T, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D. 
    Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2. 
    Neurobiol Dis. 124, 36-45 (2019) 
  • Schemmert S, Schartmann E, Zafiu C, Kass B, Hartwig S, Lehr S, Bannach O, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D. 
    Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology. 
    Mol Neurobiol. 56(3):, 2211-2223 (2019) 
  • Schwarten M, Weiergräber OH, Petrović D, Strodel B, Willbold D 
    Structural Studies of Autophagy-Related Proteins 
    Methods Mol Biol 1880, 17-56 (2019) 
  • Simons IM, Mohrlüder J, Feederle R, Kremmer E, Zobel T, Dobner J, Bleffert N, Hoffmann S, Willbold D 
    The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels 
    Sci Rep 9, 526 (2019) 
  • Van Den Berge N, Ferreira N, Gram H, Mikkelsen TW, Alstrup AKO, Casadei N, Tsung-Pin P, Riess O, Nyengaard JR, Tamgüney G, Jensen PH, Borghammer P 
    Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats 
    Acta Neuropathol 138, 535-550 (2019) 
  • Viennet T, Bungert-Pümke S, Elter S, Viegas A, Fahlke C, Etzkorn M 
    Reconstitution and NMR characterization of the ion-channel accessory subunit barttin in detergents and lipid-bilayer nanodiscs 
    Frontiers in Molecular Biosciences 6, 13 (2019) 
  • Zhang T, Gering I, Kutzsche J, Nagel-Steger L, Willbold D. 
    Toward the Mode of Action of the Clinical Stage All-d-Enantiomeric Peptide RD2 on Aβ42 Aggregation. 
    ACS Chem Neurosci. 10(12), 4800-4809. (2019) 
  • Zhang T, Loschwitz J, Strodel B, Nagel-Steger L, Willbold D. 
    Interference with Amyloid-β Nucleation by Transient Ligand Interaction. 
    Molecules 24(11), pii: E2129 (2019) 
  • Zhang T, Nagel-Steger L, Willbold D. 
    Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies. 
    ChemistryOpen 8(7), 989-994 (2019)