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Publikationen

  • Brown H, Chung M, Üffing A, Batistatou N, Tsang T, Doskocil S, Mao W, Willbold D, Bast RC Jr, Lu Z, Weiergräber OH, Kritzer JA 
    Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy 
    J Am Chem Soc 144, 14687-14697 (2022) 
    https://doi.org/10.1021/jacs.2c04699  
  • Dobner J, Simons IM, Rufinatscha K, Hänsch S, Schwarten M, Weiergräber OH, Abdollahzadeh I, Gensch T, Bode JG, Hoffmann S, Willbold D. 
    Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-induced EGFR Degradation 
    Cells 9, 1296 (2020) 
    https://doi.org/10.3390/cells9051296  
    https://www.mdpi.com/2073-4409/9/5/1296  
  • Sanwald JL, Poschmann G, Stühler K, Behrends C, Hoffmanns S, Willbold D. 
    The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles 
    Cells 9, 1468 (2020) 
    https://doi.org/10.3390/cells9061468  
    https://www.mdpi.com/2073-4409/9/6/1468  
  • Abdollahzadeh I, Hendriks J, Sanwald JL, Simons IM, Hoffmann S, Weiergräber OH, Willbold D, Gensch T 
    Autophagy-Related Proteins GABARAP and LC3B Label Structures of Similar Size but Different Shape in Super-Resolution Imaging 
    Molecules 24, E1833 (2019) 
    https://doi.org/10.3390/molecules24091833  
  • Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D 
    Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication 
    J Biol Chem 294, 7388-7402 (2019) 
    https://doi.org/10.1074/jbc.RA119.007656  
  • Simons IM, Mohrlüder J, Feederle R, Kremmer E, Zobel T, Dobner J, Bleffert N, Hoffmann S, Willbold D 
    The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels 
    Sci Rep 9, 526 (2019) 
    https://doi.org/10.1038/s41598-018-36717-1  
  • Boeske A, Schwarten M, Ma P, Tusche M, Mötter J, Möller C, Neudecker P, Hoffmann S, Willbold D 
    Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization 
    Scientific Reports 7, 5979 (2017) 
  • Hung Y-F, Schwarten M, Hoffmann S, Willbold D, Sklan EH, Koenig BW 
    Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes 
    Viruses 7, 4119-4130 (2015) 
    Link  
  • Hung Y-F, Schwarten M, Schünke S, Thiagarajan-Rosenkranz P, Hoffmann S, Sklan EH, Willbold D, Koenig BW 
    Dengue virus NS4A cytoplasmic domain binding to liposomes is sensitive to membrane curvature 
    BBA - Biomembranes 1848, 1119-1126 (2015) 
  • Aladag A, Hoffmann S, Stoldt M, Bösing C, Willbold D, Schwarten M 
    Hepatitis C virus NS5A is able to competitively displace c-Myc from the Bin1 SH3 domain in vitro 
    J. Pept. Science 20, 334-340 (2014) 
  • Hung Y-F, Valdau O, Schünke S, Stern O, Koenig BW, Willbold D, Hoffmann S 
    Recombinant production of the amino terminal cytoplasmic region of dengue virus non-structural protein 4A for structural studies 
    PLoS ONE 9, e86482 (2014) 
    Link  
  • Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D 
    Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): Biophysical characterization and functional implications 
    J Biol Chem 288, 37204-37215 (2013) 
  • Schwarten M, Solyom Z, Feuerstein S, Aladag A, Hoffmann S, Willbold D, Brutscher B 
    Interaction of non-structural protein 5A of hepatitis C virus with SH3 domains using non-canonical binding sites 
    Biochemistry 52, 6160-6168 (2013) 
  • Stern O, Hung Y-F, Valdau O, Yaffe Y, Harris E, Hoffmann S, Willbold D, Sklan E 
    An N-terminal amphipathic helix in the Dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication. 
    J. Virol. 87, 4080-4085 (2013) 
  • Feuerstein S, Plevin MJ, Willbold D, Brutscher B 
    iHADAMAC: a complementary tool for sequential resonance assignment of globular and highly disordered protein. 
    J. Magn. Res. 214, 329-334 (2012) 
  • Feuerstein S, Solyom Z, Aladag A, Favier A, Schwarten M, Hoffmann S, Willbold D, Brutscher B 
    Transient structure and SH3 interaction sites in an intrinsically disordered fragment of the hepatitis C virus protein NS5A. 
    J. Mol. Biol. 420, 310-323 (2012) 
  • Kammula E, Moetter J, Gorgels A, Jonas E, Hoffmann S, Willbold D 
    Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. 
    PLoS ONE 7, e51578 (2012) 
    http://dx.doi.org/10.1371/journal.pone.0051578  
    full text open access  
  • Feuerstein S, Solyom Z, Aladag A, Hoffmann S, Willbold D, Brutscher B 
    1H, 13C, and 15N resonance assignment of a 179 residue fragment of hepatitis C virus nonstructural protein 5A 
    Biomol. NMR Assign. 53, 241-243 (2011) 
  • Batra-Safferling R, Granzin J, Moedder S, Hoffmann S, Willbold D 
    Structural studies of PI3K SH3 domain in complex with a peptide ligand: Role of anchor residue in ligand binding. 
    Biol. Chem. 391, 33-42 (2010) 
  • Glück JM, Hoffmann S, Koenig BW, Willbold D 
    Single Vector System for Efficient N-myristoylation of Recombinant Proteins in E. coli 
    PLoS ONE 5, e10081 (2010) 
    full text open access  
    The plasmids in this publication can be received via https://www.addgene.org/Dieter_Willbold/ 
  • Hoffmann S, Funke SA, Wiesehan K, Moedder S, Glück JM, Feuerstein S, Gerdts M, Moetter J, Willbold D 
    Competitively selected protein ligands pay theirs increase in specificity by a decrease in affinity. 
    Mol. BioSyst 6, 116-123 (2010) 
  • Glück JM, Wittlich M, Feuerstein S, Hoffmann S, Willbold D, Koenig BW 
    Integral membrane proteins in nanodiscs can be studied by solution NMR spectroscopy. 
    J. Am. Chem. Soc. 131, 12060-61 (2009) 
  • Hoffmann S, Jonas E, Konig S, Preusser-Kunze A, Willbold D 
    Nef protein of human immunodeficiency virus type 1 binds its own myristoylated N-terminus. 
    Biol. Chem. 366, 181-183 (2007) 
  • Schmidt H, Hoffmann S, Tran T, Stoldt M, Stangler T, Wiesehan K, Willbold D 
    Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes. 
    J. Mol. Biol. 365, 1517-1532 (2007) 
  • Stangler T, Tran T, Hoffmann S, Schmidt H, Jonas E, Willbold D 
    Competitive displacement of full-length HIV-1 Nef from Hck SH3 domain by a high affinity artificial peptide. 
    Biol. Chem. 388, 611-615 (2007) 
  • Wittlich M, Koenig BW, Hoffmann S, Willbold D 
    Structural characterisation of the transmembrane and cytoplasmic domains of human CD4. 
    Biochim Biophys Acta 1768, 2949-60 (2007) 
  • Tran T, Hoffmann S, Wiesehan K, Jonas E, Luge C, Aladag A, Willbold D 
    Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. 
    Biochemistry 44, 15042-15052 (2005) 
  • Briese L, Hoffmann S, Friedrich U, Biesinger B, Willbold D 
    Sequence-specific 1H, 13C and 15N resonance assignments of lymphocyte specific kinase unique and SH3 domains. 
    J. Biomol. NMR 19, 193-194 (2001) 
  • Jonas G, Hoffmann S, Willbold D 
    Binding of phage displayed HIV-1 Tat to TAR RNA in the presence of Cyclin T1. 
    J. Biomed. Sci. 8, 340-346 (2001) 
  • Hoffmann S, Willbold D 
    A selection system to study protein-RNA interactions: Functional display of HIV-1 Tat protein on filamentous bacteriophage M13 
    Biochem. Biophys. Res. Comm. 235, 806-811 (1997) 
  • Metzger AU, Bayer B, Willbold D, Hoffmann S, Frank RW, Goody RS, Rösch P 
    The interaction of HIV-1 Tat (32-72) with its target RNA: A Fluorescence and Nuclear Magnetic Resonance Study 
    Biochem. Biophys. Res. Comm. 241, 31-36 (1997) 
  • Willbold D, Hoffmann S, Rösch P 
    Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution 
    Eur. J. Biochem. 245, 581-588 (1997) 
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