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Protein Misfolding and Neurodegeneration

Welcome to the pages of the Tamgüney research group!

We study neurodegenerative diseases such as Parkinson's and Alzheimer's, which affect the brain and lead to motor deficits and/or cognitive impairment and dementia. These diseases are characterized by the misfolding and aggregation of specific neuronal proteins, such as α-synuclein in Parkinson's disease or amyloid-β and tau in Alzheimer's disease, which cause neuronal damage and loss. The focus of our research work is to gain a better understanding of the cellular and systemic spread of toxic protein aggregates, to develop a diagnostic laboratory test for the early detection of Parkinson's and Alzheimer's disease, and to develop a vaccine to protect against Parkinson's disease.

On the following pages you can get an impression of our research work.

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