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NMR-based Dynamical Biology

DFG-Research Group

“The only thing that is constant is change”, especially in the domain of living matter. Biological processes are mediated by various types of biomolecular motions occurring in a broad range of time- and length-scales. The focus of our group is to develop new approaches to expand our experimental access to protein motions underlying processes such as protein folding/misfolding/aggregation, protein-protein and protein-small molecule interactions and biomolecular phase separation. The key tool in our research is solution-state NMR spectroscopy, combined with other biophysical and computational techniques whenever needed. More specifically, we are interested in understanding the mechanistic relation between the structural dynamics of neurodegeneration-related intrinsically disordered proteins and their aggregation and phase separation behaviors. The practical goal of our research is to develop new experimental tools useful for the rational design and optimization of drug-like small molecules against increasingly prevalent neurodegenerative diseases such as Alzheimer and Parkinson diseases.   


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