- Florian Bleffert, Joachim Granzin, Muttalip Caliskan, Stephan N Schott-Verdugo, Meike Siebers, Björn Thiele, Laurence Rahme, Sebastian Felgner, Peter Dörmann, Holger Gohlke* , Renu Batra-Safferling*, Karl-Erich Jaeger, Filip Kovacic*
Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa.
eLife 11, e72824 (2022)
https://doi.org/10.7554/eLife.72824
- Hemmer S, Schulte M, Knieps-Grünhagen E, Granzin J, Willbold D, Jaeger KE, Batra-Safferling R, Panwalkar V, Krauss U.
Residue alterations within a conserved hydrophobic pocket influence light, oxygen, voltage photoreceptor dark recovery.
Photochem Photobiol Sci , (2022)
https://doi.org/10.1007/s43630-022-00346-5
- Weiergräber OH, Petrović D, Kislat A, Pattky M, Fabig J, Batra-Safferling R, Schulte am Esch J, Hänel K, Huhn C, Strodel B, Homey B, Willbold D
Structure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity
Biomolecules 12, 1588 (2022)
https://doi.org/10.3390/biom12111588
- Arinkin V, Granzin J, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R.
Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida.
FEBS J 288(16), 4955-4972 (2021)
https://doi.org/10.1111/febs.15785
- Röllen K, Granzin J, Remeeva A, Davari MD, Gensch T, Nazarenko VV, Kovalev K, Bogorodskiy A, Borshchevskiy V, Hemmer S, Schwaneberg U, Gordeliy V, Jaeger KE, Batra-Safferling R, Gushchin I, Krauss U.
The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins.
J Biol Chem 296, 100662 (2021)
https://doi.org/10.1016/j.jbc.2021.100662
- Stadler AM, Granzin J, Cousin A, Batra-Safferling R.
Phosphorylated peptide of G protein-coupled receptor induces dimerization in activated arrestin.
Scientific Reports 10, 10938 (2020)
https://doi.org/10.1038/s41598-020-67944-0
- Bleffert F, Granzin J, Gohlke H, Batra-Safferling R, Jaeger KE, Kovacic F
Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization.
Acta Crystallography F75, 270-277 (2019)
https://doi.org/10.1107/S2053230X19002152
http://scripts.iucr.org/cgi-bin/paper?S2053230X19002152
- Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-RosenkranzP, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, PfefferK, Beer-Hammer S, Willbold D, Koenig BW
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association
Scientific Reports 9, 54 (2019)
https://doi.org/10.1038/s41598-018-37185-3
- Lorenz C, Ince S, Zhang T, Cousin A, Batra-Safferling R, Nagel-Steger L, Herrmann C, Stadler AM.
Farnesylation of human guanylate-binding protein 1 as safety mechanism preventing structural rearrangements and uninduced dimerization.
FEBS J Epub ahead of print, Epub ahead of print (2019)
https://doi.org/10.1111/febs.15015
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15015
- Fettweiss T, Röllen K, Granzin J, Reiners O, Endres S, Drepper T, Willbold D, Jaeger KE, Batra-Safferling R*, Krauss U*
Mechanistic Basis of the Fast Dark Recovery of the Short LOV Protein DsLOV from Dinoroseobacter shibae.
Biochemistry 57, 4833–4847 (2018)
http://dx.doi.org/10.1021/acs.biochem.8b00645
- Röllen, K.; Granzin, J.; Batra-Safferling, R*.; Stadler, A.M*.
Small-angle X-ray scattering study of the kinetics of light-dark transition in a LOV protein
PLoS One 13(7):e0200746, (2018)
http://dx.doi.org/10.1371/journal.pone.0200746
- Arinkin V, Granzin J, Röllen K, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R.
Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools
Scientific Reports 7(42971), (2017)
http://dx.doi.org/10.1038/srep42971
- Batra-Safferling R and Granzin J.
The Structure of the Polar Core Mutant R175E and Its Functional Implications.
The Structural Basis Of Arrestin Functions, Vsevolod V. Gurevich (Editor); Springer International Publishing Chapter 11, 143-158 (2017)
ISBN: 978-3-319-57552-0
- Schlesinger R, Cousin A, Granzin J, Batra-Safferling R.
Expression and purification of arrestin in yeast Saccharomyces cerevisiae.
Methods Cell Biol 142, 159-172 (2017)
https://doi.org/10.1016/bs.mcb.2017.07.003
- Kovacic F, Bleffert F, Caliskan M, Wilhelm S, Granzin J, Batra-Safferling R, Jaeger KE.
A membrane-bound esterase PA2949 from Pseudomonas aeruginosa is expressed and purified from Escherichia coli.
FEBS Open Bio. Apr 19;6(5), 484-93 (2016)
http://dx.doi.org/10.1002/2211-5463.12061
http://www.ncbi.nlm.nih.gov/pubmed/27419054
- Röllen K, Granzin J, Panwalkar V, Arinkin V, Rani R, Hartmann R, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R.
Signaling States of a Short Blue-Light Photoreceptor Protein PpSB1-LOV Revealed from Crystal Structures and Solution NMR Spectroscopy.
J Mol Biol. 428, 3721 - 3736 (2016)
http://dx.doi.org/10.1016/j.jmb.2016.05.027
http://www.ncbi.nlm.nih.gov/pubmed/27291287
- Endres S, Granzin J, Circolone F, Stadler A, Krauss U, Drepper T, Svensson V, Knieps-Grünhagen E, Wirtz A, Cousin A, Tielen P, Willbold D, Jaeger K-E, Batra-Safferling R
Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae.
BMC Microbiology 15, 30 (2015)
http://www.biomedcentral.com/1471-2180/15/30
- Granzin J, Stadler A, Cousin A, Schlesinger R, Batra-Safferling R
Structural evidence for the role of polar core residue Arg175 in arrestin activation.
Scientific Reports 5, 15808 (2015)
http://dx.doi.org/10.1038/srep15808.
http://www.nature.com/articles/srep15808
- Kovacic F, Granzin J, Wilhelm S, Kojic-Prodic B, Batra-Safferling R, Jaeger KE
Structural and Functional Characterisation of TesA - A Novel Lysophospholipase A from Pseudomonas aeruginosa.
PLoS One 8, e69125 (2013)
http://dx.doi.org/10.1371/journal.pone.0069125
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069125
- Circolone F, Granzin J, Jentzsch K, Drepper T, Jaeger K-E, Willbold D, Krauss U, Batra-Safferling R
Structural basis for the slow dark recovery of a full-length LOV protein from Pseudomonas putida.
J. Mol. Biol. 417, 362–374 (2012)
- Granzin J, Cousin A, Weirauch M, Schlesinger R, Büldt G, Batra-Safferling R
Crystal structure of p44, a constitutively active splice variant of visual arrestin.
J Mol Biol. 416(5), 611-8 (2012)
http://dx.doi.org/10.1016/j.jmb.2012.01.028
- Batra-Safferling R, Granzin J, Moedder S, Hoffmann S, Willbold D
Structural studies of PI3K SH3 domain in complex with a peptide ligand: Role of anchor residue in ligand binding.
Biol. Chem. 391, 33-42 (2010)
- Funke SA, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AHC, Müller-Schiffmann A, Korth C, Sticht H, Willbold D
Oral Treatment with the D-Enantiomeric Peptide D3 Improves Pathology and Behavior of Alzheimer’s disease Transgenic Mice
ACS Chem. Neurosci. 1, 639-648 (2010)
http://dx.doi.org/10.1021/cn100057j
Highlighted in: Chemical & Engineering News, 88(33), August 16, 2010
- Batra-Safferling R, Abaraca-Heidemann K, Körschen HG, Tziatzios C, Stoldt M, Budyak I, Willbold D, Schwalbe H, Klein-Seetharaman J, Kaupp UB
Glutamic acid-rich proteins of rod photoreceptors are natively unfolded.
J Biol Chem 281, 1449-1460 (2006)
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